Evidence map›Paper›PMID 33530397›Full record

ArticleMarine drugs2021

Chemical Synthesis and NMR Solution Structure of Conotoxin GXIA from

David A Armstrong, Ai-Hua Jin, Nayara Braga Emidio, Richard J Lewis, Paul F Alewood, K Johan Rosengren

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

David A ArmstrongSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.
Ai-Hua JinInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Nayara Braga EmidioInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0001-7835-9636
Richard J LewisInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0003-3470-923X
Paul F AlewoodInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
K Johan RosengrenSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-5007-8434
The University of Queensland · AU

Funding

Australian Research Council FT130100890National Health and Medical Research Council APP1072113
6 · The paper itself

Abstract

Conotoxins are disulfide-rich peptides found in the venom of cone snails. Due to their exquisite potency and high selectivity for a wide range of voltage and ligand gated ion channels they are attractive drug leads in neuropharmacology. Recently, cone snails were found to have the capability to rapidly switch between venom types with different proteome profiles in response to predatory or defensive stimuli. A novel conotoxin, GXIA (original name G117), belonging to the I

Indexed as

Amino Acid SequenceAnimalsConotoxinsConus SnailMagnetic Resonance SpectroscopyNeurotoxinsomega-Conotoxin GVIAProtein Structure, SecondaryProtein Structure, TertiaryConotoxinsNeurotoxinsomega-Conotoxin GVIAcone snailconotoxinConus geographusdisulfide-richinhibitor cystine knotvenom

Identifiers

PMID33530397
PMCPMC7912261
OpenAlexW3125876910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.