Evidence map›Paper›PMID 33530388›Full record

ArticlePolymers2021

Light-Responsive Polymeric Micellar Nanoparticles with Enhanced Formulation Stability.

Kyoung Nan Kim, Keun Sang Oh, Jiwook Shim, Isabel R Schlaepfer, Sana D Karam, Jung-Jae Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kyoung Nan KimDepartment of Chemistry, University of Colorado Denver, Denver, CO 80204, USA.
Keun Sang OhTGel Bio, Co, LTD, Seoul 06185, Korea.
Jiwook ShimDepartment of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, USA.ORCID 0000-0003-4088-2557
Isabel R SchlaepferDivision of Medical Oncology, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.ORCID 0000-0002-8659-9629
Sana D KaramDepartment of Radiation Oncology, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.
Jung-Jae LeeDepartment of Chemistry, University of Colorado Denver, Denver, CO 80204, USA.ORCID 0000-0003-1685-2569

Funding

Cancer League of Colorado 173991CLAS Research Innovation Award at CU Denver NAHead and Neck Cancer Career Development at Anschutz Medical Campus NAthe American Cancer Society Institutional Research Grant 16-184-56the Office of Research Services at CU Denver NAthe University of Colorado Cancer Center and Wings of Hope for Pancreatic Cancer Research NA
6 · The paper itself

Abstract

Light-sensitive polymeric micelles have recently emerged as promising drug delivery systems for spatiotemporally controlled release of payload at target sites. Here, we developed diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles that showed a change in polarity of the micellar core from hydrophobic to hydrophilic under UV light, releasing the encapsulated anti-cancer drug, doxetaxel (DTX). The micelles exhibited a low critical micelle concentration and high stability in the presence of bovine serum albumin (BSA) solution due to the hydrophobic and π-π stacking interactions in the micellar core. Cell studies showed enhanced cytotoxicity of DTX-loaded micellar nanoparticles upon irradiation. The enhanced stability would increase the circulation time of the micellar nanoparticles in blood, and enhance the therapeutic effectiveness for cancer therapy.

Indexed as

controlled release drug deliverylight-sensitive polymerpolymeric micellar nanoparticlesstimuli-responsive drug delivery

Identifiers

PMID33530388
PMCPMC7866127

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.