SynthesisNutrients2021
Calcium Supplements and Risk of Cardiovascular Disease: A Meta-Analysis of Clinical Trials.
Synthesis in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07153302 (Assessing Bone Fracture Healing Effect of Prunus Dulcis), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessing Bone Fracture Healing Effect of Prunus Dulcis (Almonds) - A Randomized Controlled Trial
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Dietary Intake of Masters Athletes: A Systematic Review.Nutrients · 2023Pooled it
- Exploring the Potential Benefits of Natural Calcium-Rich Mineral Waters for Health and Wellness: A Systematic Review.Nutrients · 2023Pooled it
- Management of glucocorticoid-induced osteoporosis in rheumatic diseases.Best practice & research. Clinical rheumatology · 2026Review
- Serum calcium levels are independently associated with severe coronary artery stenosis combined with severe cerebral artery stenosis.BMC neurology · 2026Article
- Association Between Calcium Supplementation and Recurrence of Cardiovascular Events in Patients With Cardiovascular Disease: A Population-Based Cohort Study.Journal of the American Heart Association · 2026Article
- A Scoping Review of Published Literature on the Contributions of the Natural Health Products (NHPs) Industry to Pharmacovigilance for NHPs.Drug safety · 2026Article
- Screening of probiotics for promoting mineral absorption based onFrontiers in microbiology · 2026Article
- Essential and Toxic Elements in Cardiovascular Disease: Pathophysiological Roles and the Emerging Contribution of Hair Mineral Analysis.International journal of molecular sciences · 2025Review
- Supplements for bone health.Archives of endocrinology and metabolism · 2025Review
- Calcium signalling and organelle crosstalk in cardiovascular disease: an interplay of cardiac cell death pathways.Molecular biology reports · 2025Review
- Correlation between dietary calcium intake and eczema in American adult population.Scientific reports · 2024Article
- Biomarker-Guided Dietary Supplementation: A Narrative Review of Precision in Personalized Nutrition.Nutrients · 2024Review
- Dietary recommendations of the Moroccan Society of Rheumatology (SMR) for patients with ostéosarcopenia.Archives of osteoporosis · 2024Review
- Calcium deficiency and its implications for cardiovascular disease and cancer: Strategies for resolution via agronomic fortification.Food science & nutrition · 2024Review
- Global prevalence of diet low in calcium and the disease burden: results from the Global Burden of Disease Study 2019.Nutrition & diabetes · 2024Article
- Metformin-Induced Vitamin B12 Deficiency in Patients with Type 2 Diabetes: A Narrative Review with a Practical Approach for Screening, Diagnosing, and Managing Vitamin B12 Deficiency.Korean journal of family medicine · 2024Article
- Association between Daily Dietary Calcium Intake and the Risk of Cardiovascular Disease (CVD) in Postmenopausal Korean Women.Nutrients · 2024Article
- Article
- Metabolic bone disorders and the promise of marine osteoactive compounds.Cellular and molecular life sciences : CMLS · 2023Review
- Effect of Denosumab on Bone Density in Postmenopausal Osteoporosis: A Comparison with and without Calcium Supplementation in Patients on Standard Diets in Korea.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent systematic reviews and meta-analyses of randomized, double-blind, placebo-controlled trials (double-blind, placebo-controlled RCTs) have reported controversial findings regarding the associations between calcium supplements on the risk of cardiovascular disease (CVD). This meta-analysis aimed to investigate the association between them.
methodsWe searched PubMed, EMBASE, the Cochrane Library, and the bibliographies of relevant articles for double-blind, placebo-controlled RCTs in November, 2020. Relative risks (RRs) with 95% confidence intervals (CIs) for the risk of cardiovascular disease were calculated using a random effects model. The main outcomes were CVD, coronary heart disease (CHD), and cerebrovascular disease.
resultsA total of 13 double-blind, placebo-controlled RCTs (
conclusionsThe current meta-analysis found that calcium supplements increased a risk of CVD by about 15% in healthy postmenopausal women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.