ArticleJournal of clinical medicine2021
Parity and Interval from Previous Delivery-Influence on Perinatal Outcome in Advanced Maternal Age Parturients.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Factors influencing failed vaginal trial of labor and subsequent cesarean section in elderly multiparous women, and maternal and neonatal outcomes.Frontiers in global women's health · 2026Article
- Risk factors for severe maternal morbidity in patients with hypertensive disorder of pregnancy: A retrospective study.Pakistan journal of medical sciences · 2025Article
- Association between interpregnancy interval and adverse perinatal outcomes according to maternal age in the context of China's two-child policy.BMC pregnancy and childbirth · 2025Article
- Article
- Dose-response associations of maternal age with pregnancy complications and multimorbidity among nulliparas and multiparas: A multicentric retrospective cohort study in southern China.Journal of global health · 2023Article
- The association between maternal diabetes and neonatal seizures: a nested case-Control study.Frontiers in pediatrics · 2023Article
- The role of intervening pregnancy loss in the association between interpregnancy interval and adverse pregnancy outcomes.BJOG : an international journal of obstetrics and gynaecology · 2022Article
- Special Issue: "Clinical Diagnosis and Management of Pregnancy Complications".Journal of clinical medicine · 2022Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of parity and interpregnancy interval (IPI) on perinatal outcomes in advanced maternal age (AMA) parturients.
methodsA population-based retrospective cohort study of all women older than 40 years, who had a singleton live birth after 24 weeks in the United States in 2017 Women were categorized to three groups by parity and interval from last delivery: primiparas, multiparas with IPI ≤ 5 years, and multiparas with IPI > 5 years. Primary outcome was composite adverse neonatal outcome (preterm delivery <34 weeks, birthweight <2000 g, neonatal seizure, neonatal intensive care unit admission, Apgar score <7 at 5 min, or assisted ventilation >6 h). Secondary outcome was composite adverse maternal outcome and other adverse perinatal outcomes. Univariate and multivariate analysis were used to compare between groups.
resultsDuring 2017, 3,864,754 deliveries were recorded into the database. Following exclusion, 109,564 AMA gravidas entered analysis. Of them, 24,769 (22.6%) were nulliparas, 39,933 (36.4%) were multiparas with IPI ≤ 5 years, and 44,862 (40.9%) were multiparas with IPI > 5 years. Composite neonatal outcome was higher in nulliparas and in multiparas with IPI > 5 years, in comparison to multiparas with IPI ≤ 5 years (16% vs. 13% vs. 10%, respectively,
conclusionAmong AMA gravidas, multiparity with IPI ≤ 5 years has a significant protective effect against adverse neonatal outcomes when compared to nulliparas. Multiparity with IPI > 5 years is no longer protective.
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