Evidence map›Paper›PMID 33530312›Full record

ArticleNutrients2021

Clinical Significance of Probiotics for Children with Idiopathic Nephrotic Syndrome.

Tadashi Yamaguchi, Shoji Tsuji, Shohei Akagawa, Yuko Akagawa, Jiro Kino, Sohsaku Yamanouchi, Takahisa Kimata, Masaki Hashiyada, Atsushi Akane, Kazunari Kaneko

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

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  2. Microbiology spectrum · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Tadashi YamaguchiDepartment of Pediatrics, Kansai Medical University, Osaka 573-1010, Japan.
Shoji TsujiDepartment of Pediatrics, Kansai Medical University, Osaka 573-1010, Japan.ORCID 0000-0003-3607-8355
Shohei AkagawaDepartment of Pediatrics, Kansai Medical University, Osaka 573-1010, Japan.ORCID 0000-0002-1659-4187
Yuko AkagawaDepartment of Pediatrics, Kansai Medical University, Osaka 573-1010, Japan.
Jiro KinoDepartment of Pediatrics, Kansai Medical University, Osaka 573-1010, Japan.
Sohsaku YamanouchiDepartment of Pediatrics, Kansai Medical University, Osaka 573-1010, Japan.
Takahisa KimataDepartment of Pediatrics, Kansai Medical University, Osaka 573-1010, Japan.
Masaki HashiyadaDepartment of Legal Medicine, Kansai Medical University, Osaka 573-1010, Japan.
Atsushi AkaneDepartment of Legal Medicine, Kansai Medical University, Osaka 573-1010, Japan.
Kazunari KanekoDepartment of Pediatrics, Kansai Medical University, Osaka 573-1010, Japan.ORCID 0000-0002-8215-0832
Kansai Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously reported that a decrease in butyrate-producing bacteria in the gut is a potential cause of regulatory T cell (Treg) abnormalities in children with idiopathic nephrotic syndrome (INS). Therefore, we hypothesized that administration of butyrate-producing bacteria might reduce INS relapse and the need for immunosuppressants in these patients. Twenty patients in remission from INS (median age 5.3 years, 15 boys) were enrolled in the study and assigned to receive either daily oral treatment with a preparation of 3 g

Indexed as

ButyratesChildChild, PreschoolClostridium butyricumFecesFemaleGastrointestinal MicrobiomeHumansImmunosuppressive AgentsKidney DiseasesMaleNephrotic SyndromeProbioticsRecurrenceRNA, Ribosomal, 16ST-Lymphocytes, RegulatoryButyratesImmunosuppressive AgentsRNA, Ribosomal, 16Sbutyrate-producing bacteriaidiopathic nephrotic syndromeprobioticsregulatory T cells

Identifiers

PMID33530312
PMCPMC7911438
OpenAlexW3122231884

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.