ArticleMedicine2021
Simultaneous cardio-cerebral infarction in the coronavirus disease pandemic era: A case series.
Article in Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- A case-based systematic review on the SARS-COVID-2-associated cerebrovascular diseases and the possible virus routes of entry.Journal of neurovirology · 2021Pooled it
- Secondary cardiocerebral infarction after acute inferior myocardial infarction treated with two emergency thrombectomies: a case report.Frontiers in medicine · 2025Article
- Cardio-cerebral infarction: a narrative review of pathophysiology, treatment challenges, and prognostic implications.Frontiers in cardiovascular medicine · 2025Review
- Concurrent Cardio-Cerebral Infarction - A Case Report and Literature Review.The Neurohospitalist · 2024Article
- Neurological implications of cardiac compromise in COVID-19.American journal of cardiovascular disease · 2023Review
- Simultaneous acute cardio-cerebral infarction associated with isolated left ventricle non-compaction cardiomyopathy.Annals of medicine and surgery (2012) · 2022Article
- Interaction of SARS-CoV-2 with cardiomyocytes: Insight into the underlying molecular mechanisms of cardiac injury and pharmacotherapy.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Review
- Late Onset Occurrence of Concomitant Myocardial Infarction and Ischemic Stroke in Hospitalized COVID-19 Patient: A Case Report.International journal of general medicine · 2022Article
- Successful endovascular treatment of simultaneous acute ischaemic stroke and hyperacute ST-elevation myocardial infarction: the first case report of a single-operator cardio-cerebral intervention.European heart journal. Case reports · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSimultaneous occurrence of acute ischemic stroke and myocardial infarction is reported to have variable precipitating causes. This occurrence has been rarely reported in the literature and described only in very few case reports. During the surge of coronavirus disease (COVID-19) in our region, we noted an increase in the simultaneous occurrence of cardio-cerebral infarction. This led us to explore the possible mechanisms and pathophysiology that could contribute to this increase. The retrospective nature of the study limited us from drawing any conclusion about causation. Rather, we aimed to formulate a hypothesis for future, more rigorous studies. PATIENT CONCERNS: We present an overview of 5 cases of simultaneous cardio-cerebral infarction that we encountered in our emergency department within 1 month. DIAGNOSIS: In all cases, diagnosis was confirmed using an electrocardiogram, assessment of laboratory cardiac markers, and imaging.
interventionsIn all cases, dual antiplatelet therapy was started and thrombolysis was held, as the condition was considered high risk in most of the patients. Cardiac catheterization lab was not activated either because the patient was unstable or the risk of COVID-19 in staff outweighed the benefit added in patient treatment. OUTCOMES: Two out of 5 patients died because of early complications that lasted for few days. The remaining 3 were discharged from the hospital in moderate functionality for extensive therapy and rehabilitation.
conclusionEarly recognition and immediate treatment is important in different scenarios leading to thrombosis as the outcome. Additionally, addressing the unknown risks that could contribute to our traditional understanding of these causative mechanisms is important. The hypothesis of exacerbated damage caused by inflammatory and immunological endothelial systemic damage should further be explored to be able to delineate new possibilities in managing these conditions.
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