ArticleMedical hypotheses2021
Could diet and exercise reduce risk of COVID-19 syndemic?
Article in Medical hypotheses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- The Role of Diet and Physical Activity in Shaping COVID-19 Severity: Design, Validation, and Application of a Retrospective Questionnaire.Healthcare (Basel, Switzerland) · 2024Article
- Tele-Physical Activity Promotion Program among College Students during the COVID-19 Pandemic.Medicina (Kaunas, Lithuania) · 2023Article
- NMR-Metabolomics in COVID-19 Research.Advances in experimental medicine and biology · 2023Article
- Dietary, comorbidity, and geo-economic data fusion for explainable COVID-19 mortality prediction.Expert systems with applications · 2022Article
- Knowledge of SARS-CoV-2 Epitopes and Population HLA Types Is Important in the Design of COVID-19 Vaccines.Vaccines · 2022Review
- Causal systems mapping to promote healthy living for pandemic preparedness: a call to action for global public health.The international journal of behavioral nutrition and physical activity · 2022Article
- Adherence to physical exercise recommendations among type 2 diabetes patients during the COVID-19 pandemic.International journal of Africa nursing sciences · 2022Article
- The mediating role of resilience in the effects of physical exercise on college students' negative emotions during the COVID-19 epidemic.Scientific reports · 2021Article
- Current Activities Centered on Healthy Living and Recommendations for the Future: A Position Statement from the HL-PIVOT Network.Current problems in cardiology · 2021Review
- Post pandemic research priorities: A consensus statement from the HL-PIVOT.Progress in cardiovascular diseasesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a hypothesis for increased sugar consumption and a lack of physical exercise as possible determinants of COVID-19 disease severity by impaired glucose metabolism, concurring into a syndemic. National data demonstrate that increased sugar consumption, a high daily caloric intake, and low levels of daily physical activity are independently associated with COVID-19 mortality. Further, genetic factors such as variations in the androgen receptor may compound the effects of an unhealthy lifestyle and increase the risk of severe COVID-19 symptoms in some patients. A diet high in sugar in combination with a low level of physical activity may increase blood glucose levels and impair glucose metabolism. Recent data show that patients admitted to the hospital with high levels of fasting blood glucose are at an increased risk for severe COVID-19 symptoms. Moreover, elevated glucose levels resulted in increased SARS-CoV-2 viral loads in vitro. We believe that healthier habits of diet and exercise, by improving glucose homeostasis could modulate the individual risk of severe COVID-19 symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.