ArticleChemosphere2021
Quantification of glyphosate and other organophosphorus compounds in human urine via ion chromatography isotope dilution tandem mass spectrometry.
Article in Chemosphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 81 citations in OpenAlex.
- Urinary Glyphosate Concentrations among Pregnant Participants in a Randomized, Crossover Trial of Organic and Conventional Diets.Environmental health perspectives · 2023Trial
- A robust dilute-and-inject ion chromatography - Tandem mass spectrometry for urinary glyphosate quantification.MethodsX · 2026Article
- Article
- Glyphosate exposure, bone mineral density, osteoporosis, and fractures in the United States population.Journal of environmental health science & engineering · 2026Article
- Urinary Glyphosate Exposure and Risk of Obstructive Airway Diseases in Youth and Adults: Population-Based Evidence from U.S. Biomonitoring Data.International journal of environmental research and public health · 2026Article
- Association of glyphosate exposure with kidney function impairment in the adolescents and young adults' population in the U.S. National Health and Nutrition Examination Survey, 2013 to 2016.Paediatrics & child health · 2025Article
- An Integrated Nanosensor/Smartphone Platform for Point-of-Care Biomonitoring of Human Exposure to Pesticides.Analytical chemistry · 2025Article
- The relationship between urinary glyphosate and all-cause and specific-cause mortality: a prospective study.Scientific reports · 2025Article
- Associations between environmental glyphosate exposure and glucose homeostasis indices in US general adults: a national population-based cross-sectional study.Scientific reports · 2025Article
- [Advances in the application of ion chromatography-mass spectrometry in the fields of life and health].Se pu = Chinese journal of chromatography · 2024Review
- Temporal trends of exposure to the herbicide glyphosate in the United States (2013-2018): Data from the National Health and Nutrition Examination Survey.Chemosphere · 2024Article
- Potential Role of Glyphosate, Glyphosate-Based Herbicides, and AMPA in Breast Cancer Development: A Review of Human and Human Cell-Based Studies.International journal of environmental research and public health · 2024Review
- Relationship of urinary glyphosate concentrations with glycosylated hemoglobin and diabetes in US adults: a cross-sectional study.BMC public health · 2024Article
- Urinary biomonitoring of glyphosate exposure among male farmers and nonfarmers in the Biomarkers of Exposure and Effect in Agriculture (BEEA) study.Environment international · 2024Article
- Analysis of the association between urinary glyphosate exposure and fatty liver index: a study for US adults.BMC public health · 2024Article
- Association between urinary glyphosate levels and serum neurofilament light chain in a representative sample of US adults: NHANES 2013-2014.Journal of exposure science & environmental epidemiology · 2024Article
- Association between urinary glyphosate levels and hand grip strength in a representative sample of US adults: NHANES 2013-2014.Frontiers in public health · 2024Article
- Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications.Frontiers in public health · 2024Review
- The Effect of Pesticide Spray Season and Residential Proximity to Agriculture on Glyphosate Exposure among Pregnant People in Southern Idaho, 2021.Environmental health perspectives · 2023Article
- Urinary Glyphosate, 2,4-D and DEET Biomarkers in Relation to Neurobehavioral Performance in Ecuadorian Adolescents in the ESPINA Cohort.Environmental health perspectives · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Organophosphorus pesticides are the most used pesticides in the United States. Most organophosphorus pesticides are composed of a phosphate (or phosphorothioate or phosphorodithioate) moiety and a variable organic group. Organophosphorus pesticides are scrutinized by regulatory bodies and agencies because of their toxicity or suspected carcinogenicity. Upon exposure, organophosphorus pesticides and their metabolites eliminate in urine; these urinary biomarkers are useful to evaluate human exposure. We developed a method using stable isotope dilution, ion chromatography tandem mass spectrometry for quantification in urine of 6 O,O-dialkylphosphates, metabolites of organophosphorus insecticides, and glyphosate, the most used herbicide in the United States. With simple and minimal sample preparation, the analytical method is selective and sensitive (limits of detection are 0.2-0.8 μg/L), accurate (>85%) and precise (relative standard deviation <20%), depending on the analyte. To assess the suitability of the method in real exposure scenarios, we analyzed samples collected anonymously from subjects with suspected exposure to pesticides (n = 40) or who had been on an organic diet (n = 50). We detected glyphosate in 80% of subjects reporting an organic diet and in 78% of those with suspected glyphosate exposure; concentrations ranged from <0.2 to 28.6 μg/L. Median concentrations were 0.39 μg/L for the organic diet group and 0.40 μg/L for individuals with suspected exposure. Interestingly, interquartile ranges were considerably higher among those reporting pesticide exposure (0.63 μg/L) than those consuming organic diets (0.42 μg/L). These data suggest that the method meets typical validation benchmark values and is sensitive to investigate background exposures in the general population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.