ArticleNeuron2021
Alternating sources of perisomatic inhibition during behavior.
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
What it found
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Who cites it
86 citing papers in PubMed, 158 citations in OpenAlex.
- Cannabinoid modulation of central amygdala population dynamics during threat investigation.Nature communications · 2026Article
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- Single cell RNA-sequencing reveals neuron type-specific vulnerabilities in a model of STXBP1-related disorder.Molecular psychiatry · 2026Article
- Reduction of forebrain interneurons alters cellular organization and cortical neurogenesis in a mouse model of X-linked intellectual disability.bioRxiv : the preprint server for biology · 2026Article
- Clustered inputs engage dendritic nonlinearities and calcium signaling to support efficient place-field formation in CA1 pyramidal neurons.Cell reports · 2026Article
- Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo.Nature methods · 2026Article
- AAV-mediated GPR173 gene therapy attenuates long-term refractory epilepsy by enhancing synaptic GABAActa pharmacologica Sinica · 2026Article
- Hippocampal microcircuits constrain the generation of epileptiform activity.bioRxiv : the preprint server for biology · 2026Article
- Spatiotemporally Distinct Dopamine Domains in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Designer indicators for two-photon recording of subthreshold voltage dynamics.Nature methods · 2026Article
- Designer indicators for two-photon recording of subthreshold voltage dynamics.bioRxiv : the preprint server for biology · 2026Article
- A transcriptomic axis aligns with in vivo functional dynamics in hippocampal inhibitory circuits.bioRxiv : the preprint server for biology · 2026Article
- NPAS4 refines spatial and temporal firing in CA1 pyramidal neurons.bioRxiv : the preprint server for biology · 2026Article
- Temporal Coding rather than Circuit Wiring allows Hippocampal CA3 Neurons to Dynamically Distinguish Different Cortical Inputs.bioRxiv : the preprint server for biology · 2026Article
- Disorganized Inhibitory Dynamics in Hippocampal area CA1 of 22q11.2 Deletion Mutant Mice.bioRxiv : the preprint server for biology · 2026Article
- Review
- Anxiety and Beyond: Diversity in Ventral Hippocampus Circuits and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Synaptic communication within the microcircuits of pyramidal neurons and basket cells in the mouse prefrontal cortex.The Journal of physiology · 2025Article
- Noncanonical circuits, states, and computations of the hippocampus.Science (New York, N.Y.) · 2025Review
- Cooperative actions of interneuron families support the hippocampal spatial code.Science (New York, N.Y.) · 2025Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 5 institutions in 1 country.
Funding
Abstract
Interneurons expressing cholecystokinin (CCK) and parvalbumin (PV) constitute two key GABAergic controllers of hippocampal pyramidal cell output. Although the temporally precise and millisecond-scale inhibitory regulation of neuronal ensembles delivered by PV interneurons is well established, the in vivo recruitment patterns of CCK-expressing basket cell (BC) populations has remained unknown. We show in the CA1 of the mouse hippocampus that the activity of CCK BCs inversely scales with both PV and pyramidal cell activity at the behaviorally relevant timescales of seconds. Intervention experiments indicated that the inverse coupling of CCK and PV GABAergic systems arises through a mechanism involving powerful inhibitory control of CCK BCs by PV cells. The tightly coupled complementarity of two key microcircuit regulatory modules demonstrates a novel form of brain-state-specific segregation of inhibition during spontaneous behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.