Evidence map›Paper›PMID 33529446›Full record

ArticleActa ophthalmologica2021

Effect of age on reoperation rate in children undergoing exotropia surgery.

Hwan Heo, Scott R Lambert

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Acta ophthalmologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07446621 (Risk Factors And Surgical Outcomes Of Strabismus Reoperation), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07446621 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Risk Factors And Surgical Outcomes Of Strabismus Reoperation: A Clinical Study

TypeinterventionalSponsorAssiut UniversityRan2026 to 2027Enrolled62ConditionsStrabismus, Esotropia, ExotropiaArmsHorizontal Strabismus Reoperation
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Analysis of Strabismus Surgical Outcomes: A Retrospective Study of 2269 Cases from a Single Center.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Hwan HeoDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.ORCID https://orcid.org/0000-0003-2169-8770
Scott R LambertDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.ORCID https://orcid.org/0000-0002-7555-0715
Chonnam National University Hospital · KRStanford University · US

Funding

Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
NCATS NIH HHS UL1 TR001085NEI NIH HHS P30 EY026877Research to Prevent Blindness
6 · The paper itself

Abstract

purposeTo determine the effect of age on the reoperation rate in children undergoing exotropia surgery.

methodsThis was a population-based retrospective cohort study using claims data that included children ≤ 12 years who had undergone exotropia surgery as the first strabismus operation and had ≥ 3 years of continuous enrolment were selected from the Optum de-identified Clinformatics Data Mart Database (2003-2019). Patient age at the first exotropia surgery was grouped into three categories; 0-3, 4-6, and 7-12 years. We assessed the sex, race, age, surgical methods, continuous enrolment period after the first surgery, and the time between the first surgery and reoperation. Cox regression analysis was used to estimate the risk of reoperation at different ages. The hazard ratio of reoperation in children undergoing exotropia surgery according to the age at the first exotropia surgery.

resultsAmong 2015 children, 312 (15.5%) underwent one or more reoperations. A reoperation was more often performed for recurrent exotropia (n = 231) than for consecutive esotropia (n = 81). The time between the first surgery and reoperation was shorter for reoperation for consecutive esotropia (376 days) than for recurrent exotropia (672 days) (p < 0.001). Younger children showed a higher reoperation hazard ratio than older children (p < 0.001). In reoperation for consecutive esotropia, the patients aged 0-3 years showed a high hazard ratio (2.82; 95% CI, 1.59-5.01).

conclusionChildren undergoing exotropia surgery at a younger age have a higher reoperation rate than those undergoing surgery at an older age.

Indexed as

ChildChild, PreschoolExotropiaFemaleFollow-Up StudiesHumansIncidenceInfantInfant, NewbornMaleOculomotor MusclesOphthalmologic Surgical ProceduresPopulation SurveillancePostoperative ComplicationsRecurrenceReoperationageconsecutive esotropiaexotropiareoperation

Identifiers

PMID33529446
PMCPMC10233362
OpenAlexW3129161048

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.