ArticlePloS one2021
Phenotypic and genotypic virulence features of staphylococcal strains isolated from difficult-to-treat skin and soft tissue infections.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Safety and Efficacy of Vancomycin-Gentamicin PMMA Bead Pouch Therapy in the Management of Pyogenic Soft Tissue Infections of the Extremities: A Case Series of 19 Patients.Antibiotics (Basel, Switzerland) · 2026Article
- Targeting polymicrobial skin infections in atopic dermatitis: role ofFrontiers in microbiology · 2026Article
- Anti-Biofilm Properties of Cell-Free Supernatant fromMicroorganisms · 2025Article
- Prevalence, Antimicrobial Resistance, and Virulence Potential ofAntibiotics (Basel, Switzerland) · 2025Article
- Promising Antimicrobial Activities of Essential Oils and Probiotic Strains on Chronic Wound Bacteria.Biomedicines · 2025Article
- Phenotypic and Genotypic Bacterial Virulence and Resistance Profiles in Hidradenitis Suppurativa.International journal of molecular sciences · 2025Article
- Insights into Molecular Profiles, Resistance Patterns, and Virulence Traits of Staphylococci from Companion Dogs in Angola.Animals : an open access journal from MDPI · 2025Article
- Commercial Day-Old Chicks in Nigeria Are Potential Reservoirs of Colistin- and Tigecycline-Resistant Potentially PathogenicAntibiotics (Basel, Switzerland) · 2024Article
- Characterization of virulence factors and antimicrobial resistance in Staphylococcus spp. isolated from clinical samples.Folia microbiologica · 2024Article
- Quorum quenching mediated biofilm impediment inHeliyon · 2024Article
- COVID-19 and flu vaccination in Romania, post pandemic lessons in healthcare workers and general population.PloS one · 2024Observational
- Biofilm-Mediated Heavy Metal Removal from Aqueous System by Multi-Metal-Resistant Bacterial Strain Bacillus sp. GH-s29.Applied biochemistry and biotechnology · 2023Article
- Ageing People Living with HIV/AIDS, PLWHA; More Dental Challenges; the Romanian Dental Professional's Point of View.Life (Basel, Switzerland) · 2023Article
- Review
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- Cumulative Antibiogram: A Rapid Method to Hinder Transmission of Resistant Bacteria to Oral Cavity of Newborn Babies.Antibiotics (Basel, Switzerland) · 2023Article
- Clinical and microbiological features of host-bacterial interplay in chronic venous ulcersFrontiers in microbiology · 2023Article
- Antimicrobial Efficiency of Some Essential Oils in Antibiotic-ResistantPlants (Basel, Switzerland) · 2022Article
- May Staphylococcus lugdunensis Be an Etiological Factor of Chronic Maxillary Sinuses Infection?International journal of molecular sciences · 2022Article
- Composite Drug Delivery System Based on Amorphous Calcium Phosphate-Chitosan: An Efficient Antimicrobial Platform for Extended Release of Tetracycline.Pharmaceutics · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic infections represent an important burden on the healthcare system and have a significant impact on the patients' quality of life. While Staphylococcus spp. are commensal bacteria, they can become pathogenic, leading to various types of infections. In this study we aimed to characterize the virulence profiles of staphylococcal strains involved in difficult-to-treat skin and soft tissue infections, from both phenotypic and genotypic points of view. Phenotypic ability of the strains to secrete soluble virulence factors was assessed by a culturing dependent assay and their capacity to develop biofilms on inert substrate was screened by an adapted crystal violet microtiter method. We also tested the presence of several virulence genes by PCR. Most of the studied strains were isolated from purulent secretions of acne lesions and frequently secreted two or three soluble virulence factors. Most frequently secreted soluble virulence factors were caseinase (89%), lipase (71%) and lecithinase (67%). Almost half of the strains produced a well-represented biofilm. The molecular characterization showed the presence of the genes cna, hlg, clfA, and clfB. Staphylococcal strains that produce difficult-to-treat skin and soft tissue infections seem to be characterized by an enhanced ability to produce different soluble virulence factors and to develop biofilms in vitro. Further studies need to be developed in other Staphylococcus spp. infections in order to confirm this hypothesis.
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