ArticlePloS one2021
White blood cell count and incidence of hypertension in the general Japanese population: ISSA-CKD study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between hypertension and impaired lung function among adults: A systematic review and meta-analysis.PloS one · 2026Pooled it
- Gas chromatography-mass spectrometry-based plasma metabolomics analysis in hypertensive patients with Yin deficiency and Yang hyperactivity syndrome.World journal of experimental medicine · 2025Trial
- Alcohol consumption and the incidence of hyperuricemia in Japanese men and women.Scientific reports · 2026Article
- U-Shaped Relationship Between White Blood Cell Counts and Incident Hypertension in Military Young Adults: The CHIEF Study, 2014-2020.Immunity, inflammation and disease · 2025Article
- Blood indices of inflammation and their association with hypertension in smokers: analysis using data mining approaches.Journal of human hypertension · 2025Article
- TheJournal of personalized medicine · 2024Article
- The possible role of the vasopressin system in hematopoiesis.Scientific reports · 2024Article
- White blood cell and platelet distribution widths are associated with hypertension: data mining approaches.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- A link between white blood cell count and blood pressure levels.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Decreased natural killer cell activity as a potential predictor of hypertensive incidence.Frontiers in immunology · 2024Article
- Sex-Specific Associations Between Leucocyte Measures and Obstructive Sleep Apnea in Han Chinese.Nature and science of sleep · 2024Article
- Observational
- Elevation in white blood cell count and development of hyper LDL cholesterolemia.Scientific reports · 2023Article
- Serum triglyceride levels and incidence of hypertension in a general Japanese population: ISSA-CKD study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Combining multiaspect factors to predict the risk of childhood hypertension incidence.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Association of the MACROD2 rs6110695 A>G polymorphism with an increasing WBC count in a Korean population.Immunity, inflammation and disease · 2022Article
- Continuous Positive Linear Association between the Monocyte to High-Density Lipoprotein Cholesterol Ratio and Hypertension: A Cross-Sectional Study.International journal of hypertension · 2022Article
- Effect of chronic kidney disease on the association between hyperuricemia and new-onset hypertension in the general Japanese population: ISSA-CKD study.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD).Journal of clinical medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to clarify the relationship between the white blood cell (WBC) count and hypertension in the general Japanese population.
methodsWe conducted a population-based retrospective cohort study using annual health check-up data of residents of Iki City, Nagasaki Prefecture, Japan. A total of 2935 participants without hypertension at baseline were included in the present analysis. WBC counts were classified as tertile 1 (<4700/μL), tertile 2 (4700-5999/μL), and tertile 3 (≥6000/μL). The outcome was incident hypertension (blood pressure ≥140 mmHg). Multivariable-adjusted hazard ratios and 95% confidence intervals (95% CIs) were estimated using the Cox proportional hazards model.
resultDuring an average follow-up of 4.5 years, 908 participants developed hypertension. The incidence (per 100 person-years) of hypertension increased with an elevation in the WBC count (6.3 in tertile 1, 7.0 in tertile 2, and 7.4 in tertile 3). This association was significant, even after adjustment for other risk factors, including age, sex, current smoking habits, current alcohol intake, exercise habits, obesity, elevated blood pressure, diabetes mellitus, and dyslipidemia. The hazard ratios were 1.07 for tertile 2 (95% CI 0.90-1.26) and 1.27 for tertile 3 (95% CI 1.06-1.51) compared with the reference group of tertile 1 (p = 0.009).
conclusionThe WBC count was associated with future development of hypertension in the general Japanese population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.