ArticlePLoS biology2021
Systematic analyses of the MIR172 family members of Arabidopsis define their distinct roles in regulation of APETALA2 during floral transition.
Article in PLoS biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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47 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
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- Time-dependent bistability leads to critical slowing down during floral transition in Arabidopsis.Nature communications · 2026Article
- Mineral nutrients as regulators of plant flowering time: A molecular perspective.Journal of integrative plant biology · 2026Review
- A miR172e/Plants (Basel, Switzerland) · 2026Article
- MicroRNAs-mediated heat stress regulations in plants: Mechanisms and targets.The plant genome · 2025Review
- Tobacco rattle virus infection alters Arabidopsis gene expression via virus-derived SiRNAs and host MiRNA network disruption.BMC genomics · 2025Article
- The MIR157-SPL15 module regulates flowering and inflorescence development in Arabidopsis thaliana under short days and in Arabis alpina.PLoS genetics · 2025Article
- Root-derived cytokinin regulates Arabidopsis flowering time through components of the age pathway.Plant physiology · 2025Article
- miRNA-seq analysis revealed a potential strategy underlying poplar root responses to low nitrogen stress.Planta · 2025Article
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- Genome-wide analysis of miR172-mediated response to heavy metal stress in chickpea (Cicer arietinum L.): physiological, biochemical, and molecular insights.BMC plant biology · 2024Article
- Characterization and expression analysis of the MADS-box gene AGL8 in cotton: insights into gene function differentiation in plant growth and stress resistance.Molecular biology reports · 2024Article
- Coordination of shoot apical meristem shape and identity by APETALA2 during floral transition in Arabidopsis.Nature communications · 2024Article
- APETALA2-like Floral Homeotic Protein Up-RegulatingInternational journal of molecular sciences · 2024Article
- Flowering time: From physiology, through genetics to mechanism.Plant physiology · 2024Review
- The APETALA2-MYBL2 module represses proanthocyanidin biosynthesis by affecting formation of the MBW complex in seeds of Arabidopsis thaliana.Plant communications · 2024Article
- A 49-bp deletion ofHorticulture research · 2024Article
- Temporal regulation of vegetative phase change in plants.Developmental cell · 2024Review
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12 authors at 2 institutions in 2 countries.
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Abstract
MicroRNAs (miRNAs) play important roles in regulating flowering and reproduction of angiosperms. Mature miRNAs are encoded by multiple MIRNA genes that can differ in their spatiotemporal activities and their contributions to gene regulatory networks, but the functions of individual MIRNA genes are poorly defined. We functionally analyzed the activity of all 5 Arabidopsis thaliana MIR172 genes, which encode miR172 and promote the floral transition by inhibiting the accumulation of APETALA2 (AP2) and APETALA2-LIKE (AP2-LIKE) transcription factors (TFs). Through genome editing and detailed confocal microscopy, we show that the activity of miR172 at the shoot apex is encoded by 3 MIR172 genes, is critical for floral transition of the shoot meristem under noninductive photoperiods, and reduces accumulation of AP2 and TARGET OF EAT2 (TOE2), an AP2-LIKE TF, at the shoot meristem. Utilizing the genetic resources generated here, we show that the promotion of flowering by miR172 is enhanced by the MADS-domain TF FRUITFULL, which may facilitate long-term silencing of AP2-LIKE transcription, and that their activities are partially coordinated by the TF SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 15. Thus, we present a genetic framework for the depletion of AP2 and AP2-LIKE TFs at the shoot apex during floral transition and demonstrate that this plays a central role in floral induction.
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