ArticleRadiology2021
Disruption of the Atrophy-based Functional Network in Multiple Sclerosis Is Associated with Clinical Disability: Validation of a Meta-Analytic Model in Resting-State Functional MRI.
Open access · greenAbstract read
In one paragraph
Article in Radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 28% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- Co-alteration Network Architecture of Major Depressive Disorder: A Multi-modal Neuroimaging Assessment of Large-scale Disease Effects.Neuroinformatics · 2023Pooled it
- Invariant structural and functional brain regions associated with tinnitus: A meta-analysis.PloS one · 2022Pooled it
- Clinically Relevant Patterns of Co-Fluctuating Structure and Function in Multiple Sclerosis.European journal of neurology · 2025Article
- Thirty years of SPM-BrainMap synergy: making and mining coordinate-based literature.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Claustrum Volume Is Reduced in Multiple Sclerosis and Predicts Disability.Annals of clinical and translational neurology · 2025Article
- Changes in functional connectivity in relapsing-remitting multiple sclerosis spinal cord measured via region-based and data-driven analyses.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A systematic literature review of the association between global brain atrophy and the Expanded Disability Status Scale score in people with multiple sclerosis.Therapeutic advances in neurological disorders · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Florence L ChiangFrom the Department of Radiology (F.L.C., B.T., P.T.F.), Research Imaging Institute (F.L.C., C.G.F., S.D., J.P.G., P.T.F.), Joe R. and Teresa Lozano Long School of Medicine (F.L.C., M.F., R.S.R., B.T., P.T.F.), and Department of Neurology (R.S.R., P.T.F.), The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC7800, San Antonio, TX 78229-3900; Division of Methodology, Measurement and Statistical Analysis, Texas State University, San Marcos, Tex (L.P.); Department of Radiology, Division of Neuroradiology, The University of Texas Southwestern Medical Center, Dallas, Tex (F.F.Y.); Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Mass (S.Y.H.); Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Boston, Mass (S.Y.H.); and South Texas Veteran Health Care System, Research Service, San Antonio, Tex (P.T.F.).ORCID 0000-0002-3405-5590
Max FengFrom the Department of Radiology (F.L.C., B.T., P.T.F.), Research Imaging Institute (F.L.C., C.G.F., S.D., J.P.G., P.T.F.), Joe R. and Teresa Lozano Long School of Medicine (F.L.C., M.F., R.S.R., B.T., P.T.F.), and Department of Neurology (R.S.R., P.T.F.), The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC7800, San Antonio, TX 78229-3900; Division of Methodology, Measurement and Statistical Analysis, Texas State University, San Marcos, Tex (L.P.); Department of Radiology, Division of Neuroradiology, The University of Texas Southwestern Medical Center, Dallas, Tex (F.F.Y.); Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Mass (S.Y.H.); Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Boston, Mass (S.Y.H.); and South Texas Veteran Health Care System, Research Service, San Antonio, Tex (P.T.F.).ORCID 0000-0002-7042-6213
Rebecca S RomeroFrom the Department of Radiology (F.L.C., B.T., P.T.F.), Research Imaging Institute (F.L.C., C.G.F., S.D., J.P.G., P.T.F.), Joe R. and Teresa Lozano Long School of Medicine (F.L.C., M.F., R.S.R., B.T., P.T.F.), and Department of Neurology (R.S.R., P.T.F.), The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC7800, San Antonio, TX 78229-3900; Division of Methodology, Measurement and Statistical Analysis, Texas State University, San Marcos, Tex (L.P.); Department of Radiology, Division of Neuroradiology, The University of Texas Southwestern Medical Center, Dallas, Tex (F.F.Y.); Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Mass (S.Y.H.); Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Boston, Mass (S.Y.H.); and South Texas Veteran Health Care System, Research Service, San Antonio, Tex (P.T.F.).ORCID 0000-0002-1576-5597
Larry PriceFrom the Department of Radiology (F.L.C., B.T., P.T.F.), Research Imaging Institute (F.L.C., C.G.F., S.D., J.P.G., P.T.F.), Joe R. and Teresa Lozano Long School of Medicine (F.L.C., M.F., R.S.R., B.T., P.T.F.), and Department of Neurology (R.S.R., P.T.F.), The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC7800, San Antonio, TX 78229-3900; Division of Methodology, Measurement and Statistical Analysis, Texas State University, San Marcos, Tex (L.P.); Department of Radiology, Division of Neuroradiology, The University of Texas Southwestern Medical Center, Dallas, Tex (F.F.Y.); Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Mass (S.Y.H.); Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Boston, Mass (S.Y.H.); and South Texas Veteran Health Care System, Research Service, San Antonio, Tex (P.T.F.).ORCID 0000-0001-6413-1286
Crystal G FranklinFrom the Department of Radiology (F.L.C., B.T., P.T.F.), Research Imaging Institute (F.L.C., C.G.F., S.D., J.P.G., P.T.F.), Joe R. and Teresa Lozano Long School of Medicine (F.L.C., M.F., R.S.R., B.T., P.T.F.), and Department of Neurology (R.S.R., P.T.F.), The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC7800, San Antonio, TX 78229-3900; Division of Methodology, Measurement and Statistical Analysis, Texas State University, San Marcos, Tex (L.P.); Department of Radiology, Division of Neuroradiology, The University of Texas Southwestern Medical Center, Dallas, Tex (F.F.Y.); Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Mass (S.Y.H.); Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Boston, Mass (S.Y.H.); and South Texas Veteran Health Care System, Research Service, San Antonio, Tex (P.T.F.).ORCID 0000-0002-7382-1315
Shengwen DengFrom the Department of Radiology (F.L.C., B.T., P.T.F.), Research Imaging Institute (F.L.C., C.G.F., S.D., J.P.G., P.T.F.), Joe R. and Teresa Lozano Long School of Medicine (F.L.C., M.F., R.S.R., B.T., P.T.F.), and Department of Neurology (R.S.R., P.T.F.), The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC7800, San Antonio, TX 78229-3900; Division of Methodology, Measurement and Statistical Analysis, Texas State University, San Marcos, Tex (L.P.); Department of Radiology, Division of Neuroradiology, The University of Texas Southwestern Medical Center, Dallas, Tex (F.F.Y.); Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Mass (S.Y.H.); Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Boston, Mass (S.Y.H.); and South Texas Veteran Health Care System, Research Service, San Antonio, Tex (P.T.F.).ORCID 0000-0002-2026-3882
Jodie P GrayFrom the Department of Radiology (F.L.C., B.T., P.T.F.), Research Imaging Institute (F.L.C., C.G.F., S.D., J.P.G., P.T.F.), Joe R. and Teresa Lozano Long School of Medicine (F.L.C., M.F., R.S.R., B.T., P.T.F.), and Department of Neurology (R.S.R., P.T.F.), The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC7800, San Antonio, TX 78229-3900; Division of Methodology, Measurement and Statistical Analysis, Texas State University, San Marcos, Tex (L.P.); Department of Radiology, Division of Neuroradiology, The University of Texas Southwestern Medical Center, Dallas, Tex (F.F.Y.); Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Mass (S.Y.H.); Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Boston, Mass (S.Y.H.); and South Texas Veteran Health Care System, Research Service, San Antonio, Tex (P.T.F.).ORCID 0000-0001-7015-2980
Fang F YuFrom the Department of Radiology (F.L.C., B.T., P.T.F.), Research Imaging Institute (F.L.C., C.G.F., S.D., J.P.G., P.T.F.), Joe R. and Teresa Lozano Long School of Medicine (F.L.C., M.F., R.S.R., B.T., P.T.F.), and Department of Neurology (R.S.R., P.T.F.), The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC7800, San Antonio, TX 78229-3900; Division of Methodology, Measurement and Statistical Analysis, Texas State University, San Marcos, Tex (L.P.); Department of Radiology, Division of Neuroradiology, The University of Texas Southwestern Medical Center, Dallas, Tex (F.F.Y.); Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Mass (S.Y.H.); Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Boston, Mass (S.Y.H.); and South Texas Veteran Health Care System, Research Service, San Antonio, Tex (P.T.F.).ORCID 0000-0001-9913-1331
Bundhit TantiwongkosiFrom the Department of Radiology (F.L.C., B.T., P.T.F.), Research Imaging Institute (F.L.C., C.G.F., S.D., J.P.G., P.T.F.), Joe R. and Teresa Lozano Long School of Medicine (F.L.C., M.F., R.S.R., B.T., P.T.F.), and Department of Neurology (R.S.R., P.T.F.), The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC7800, San Antonio, TX 78229-3900; Division of Methodology, Measurement and Statistical Analysis, Texas State University, San Marcos, Tex (L.P.); Department of Radiology, Division of Neuroradiology, The University of Texas Southwestern Medical Center, Dallas, Tex (F.F.Y.); Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Mass (S.Y.H.); Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Boston, Mass (S.Y.H.); and South Texas Veteran Health Care System, Research Service, San Antonio, Tex (P.T.F.).ORCID 0000-0002-1397-7836
Susie Y HuangFrom the Department of Radiology (F.L.C., B.T., P.T.F.), Research Imaging Institute (F.L.C., C.G.F., S.D., J.P.G., P.T.F.), Joe R. and Teresa Lozano Long School of Medicine (F.L.C., M.F., R.S.R., B.T., P.T.F.), and Department of Neurology (R.S.R., P.T.F.), The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC7800, San Antonio, TX 78229-3900; Division of Methodology, Measurement and Statistical Analysis, Texas State University, San Marcos, Tex (L.P.); Department of Radiology, Division of Neuroradiology, The University of Texas Southwestern Medical Center, Dallas, Tex (F.F.Y.); Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Mass (S.Y.H.); Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Boston, Mass (S.Y.H.); and South Texas Veteran Health Care System, Research Service, San Antonio, Tex (P.T.F.).ORCID 0000-0003-2950-7254
Peter T FoxFrom the Department of Radiology (F.L.C., B.T., P.T.F.), Research Imaging Institute (F.L.C., C.G.F., S.D., J.P.G., P.T.F.), Joe R. and Teresa Lozano Long School of Medicine (F.L.C., M.F., R.S.R., B.T., P.T.F.), and Department of Neurology (R.S.R., P.T.F.), The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC7800, San Antonio, TX 78229-3900; Division of Methodology, Measurement and Statistical Analysis, Texas State University, San Marcos, Tex (L.P.); Department of Radiology, Division of Neuroradiology, The University of Texas Southwestern Medical Center, Dallas, Tex (F.F.Y.); Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Mass (S.Y.H.); Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Boston, Mass (S.Y.H.); and South Texas Veteran Health Care System, Research Service, San Antonio, Tex (P.T.F.).
The University of Texas Health Science Center at San Antonio · USTexas State University · US
Funding
Training and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl · 2020 to 2026
$10.9MMeta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5MCharacterizing axonal damage in multiple sclerosis using TractCaliber MRIK23NS096056 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, SUSIE YI · 2016 to 2020
$877kResearch Training for Radiology Residents, San Antonio, TexasR25EB016631 · NIBIB · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2014 to 2018
$335kNIBIB NIH HHS P41 EB030006NIBIB NIH HHS R25 EB016631NIMH NIH HHS R01 MH074457NINDS NIH HHS K23 NS096056
Abstract
Background In multiple sclerosis (MS), gray matter (GM) atrophy exhibits a specific pattern, which correlates strongly with clinical disability. However, the mechanism of regional specificity in GM atrophy remains largely unknown. Recently, the network degeneration hypothesis (NDH) was quantitatively defined (using coordinate-based meta-analysis) as the atrophy-based functional network (AFN) model, which posits that localized GM atrophy in MS is mediated by functional networks. Purpose To test the NDH in MS in a data-driven manner using the AFN model to direct analyses in an independent test sample. Materials and Methods Model fit testing was conducted with structural equation modeling, which is based on the computation of semipartial correlations. Model verification was performed in coordinate-based data of healthy control participants from the BrainMap database (
Indexed as
AdultAtrophyDisability EvaluationFemaleGray MatterHumansMagnetic Resonance ImagingMaleMultiple Sclerosis, Relapsing-RemittingProspective Studies
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