ArticleInternational journal of clinical pharmacy2021
Impact of clinical pharmacist services on quality adjusted life years in head and neck cancer patients.
Article in International journal of clinical pharmacy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Development of well-being assessment criteria for pharmacists: a mixed-methods study in the Eastern Special Development Zone of Thailand.Journal of pharmaceutical policy and practice · 2026Article
- Clinical pharmacists and nurses in the management of oral mucositis in head and neck cancer patients during antineoplastic therapy: A scoping review.SAGE open medicine · 2025Review
- Designing and psychometric evaluation of pharmacists' attitude toward ethical challenges questionnaire in pharmacy practice: A mixed‑method study.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2023Article
- Impact of cetuximab plus cisplatin alone and cetuximab plus cisplatin and paclitaxel regimen on humanistic outcome in head and neck cancer.Journal of the Egyptian National Cancer Institute · 2023Observational
- Community pharmacists' measurement of health-related quality of life for breast cancer with positive hormone receptors: A prospective observational study.SAGE open medicine · 2023Article
- Immunomodulatory Therapy in Head and Neck Squamous Cell Carcinoma: Recent Advances and Clinical Prospects.Technology in cancer research & treatmentReview
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
BackgroundThe role of clinical pharmacists in the provision of patient care is evolving in developing countries such as India. However, their acceptance in health care setups remains debatable. Objective This study aims to investigate the change in quality adjusted life-years after providing clinical pharmacist services in head and neck cancer patients. Setting Oncology speciality private centre in West India. Method It was a prospective, multi-centered pre-post study. Patients were recruited into the control group and intervention group. Clinical pharmacist services were provided only to the intervention group. The quality adjusted life-years was measured by incorporating the EQ-5D-5L instrument. Patients have been provided with the EQ-5D-5L questionnaire at the pre-determined intervals i.e. before beginning of each chemotherapy cycles till the completion of treatment. The analysis was carried out using descriptive analysis and student's t-test. Main outcome measures Change in quality adjusted life-years amongst control and intervention groups of head and neck patients. Results A total of 104 patients were recruited, out of which 50 patients were in control group and 54 patients in intervention group. Docetaxel, cisplatin, 5-fluorouracul regimen, paclitaxel-carboplatin regimen and weekly cisplatin were prescribed in majority of the head and neck patients (control group: 82%; intervention group: 74.1%). The majority of patients in the control group were facing medication-related problems such as irrational administration of chemotherapy (18.9%), lack of optimal supportive care (18.9), negligence of co-morbid conditions (16.1%), improper chemo-drug calculation (14.9%) and drug interaction (13.2%). The remedial action was provided by clinical pharmacist to overcome these medication-related problems in intervention group. The quality adjusted life-years significantly decreased in the control group from 0.012 to 0.005, however, it remained constant in the intervention group from 0.013 to 0.014 after the completion of 6 chemotherapy cycles. Conclusion The incorporation of clinical pharmacist services has helped us in identifying and understanding the various types of medication-related problems and their potential causes in patients suffering from head and neck cancer. Moreover, it helped to improve the quality adjusted life-years and decrease adverse drug reactions, reflecting positive impact on patient care.
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