ReviewSports medicine (Auckland, N.Z.)2021
The Potential Role of Exercise-Induced Muscle Damage in Exertional Heat Stroke.
Review in Sports medicine (Auckland, N.Z.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Occupational heatstroke-induced acute kidney injury: a narrative review of mechanisms, biomarkers, and the timing of blood purification initiation.Renal failure · 2026Review
- Exertional heat stroke-related acute kidney injury: novel animal and cellular models.Renal failure · 2026Article
- Changes in body mass and urinary biomarkers after a long-lasting combat search and rescue military exercise performed in a tropical region.Sports medicine and health science · 2025Article
- Cold-water immersion alleviates intestinal damage induced by exertional heat stroke via modulation of gut microbiota in rats.Frontiers in microbiomes · 2025Article
- Environmental temperature and seasonal variations as risk factors for Achilles tendon rupture: a multi-center retrospective study in China.Frontiers in public health · 2025Article
- Nutritional Considerations in Exercise-Based Heat Acclimation: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2024Review
- Serum myoglobin modulates kidney injury via inducing ferroptosis after exertional heatstroke.Journal of translational internal medicine · 2023Article
- Workers' Perception Heat Stress: Results from a Pilot Study Conducted in Italy during the COVID-19 Pandemic in 2020.International journal of environmental research and public health · 2022Article
- A mouse model of exertional heatstroke-related acute kidney injury.Annals of translational medicine · 2022Article
- Association of D-dimer and acute kidney injury associated with rhabdomyolysis in patients with exertional heatstroke: an over 10-year intensive care survey.Renal failure · 2021Article
- Effect of Multiple-Nutrient Supplement on Muscle Damage, Liver, and Kidney Function After Exercising Under Heat: Based on a Pilot Study and a Randomised Controlled Trial.Frontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exertional heat stroke (EHS) is a life-threatening condition that affects mainly athletes, military personnel, firefighters, and occupational workers. EHS is frequently observed in non-compensable conditions (where the body is unable to maintain a steady thermal balance) as a result of heavy heat stress and muscle contraction associated with prolonged and strenuous physical and occupational activities, resulting in central nervous system dysfunction followed by multi-organ damage and failure. Since the pathophysiology of EHS is complex and involves multiple organs and systems, any condition that changes the interrelated systems may increase the risk for EHS. It has been suggested that exercise-induced muscle damage (EIMD) can lead to thermoregulatory impairment and systemic inflammation, which could be a potential predisposing factor for EHS. In this review article, we aim to (1) address the evidence of EIMD as a predisposing factor for EHS and (2) propose a possible mechanism of how performing muscle-damaging exercise in the heat may aggravate muscle damage and subsequent risk of EHS and acute kidney injury (AKI). Such an understanding could be meaningful to minimize the risks of EHS and AKI for individuals with muscle damage due to engaging in physical work in hot environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.