Evidence map›Paper›PMID 33528757›Full record

Observational studyJournal of endocrinological investigation2021

Depression: another cortisol-related comorbidity in patients with adrenal incidentalomas and (possible) autonomous cortisol secretion.

A S Šojat, B Dunjić-Kostić, L V Marina, M Ivović, N V Radonjić, A Kendereški, A Ćirković, M Tančić-Gajić, Z Arizanović, S Mihajlović and 1 more

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07573163 (A Randomized Clinical Trial of Tirzepatide Following Adrenalectomy in Mild Autonomous Cortisol Secretion), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07573163 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomized Clinical Trial of Tirzepatide Following Adrenalectomy in Mild Autonomous Cortisol Secretion

TypeinterventionalSponsorAlaa SadaRan2026 to 2028Enrolled34ConditionsMild Autonomous Cortisol Secretion (MACS), Adrenalectomy, StatusArmsTirzepatide, Standard medical treatment
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. An Overlooked Disease: Minimal Autonomous Cortisol Secretion (MACS). A Narrative Review.Endocrine, metabolic & immune disorders drug targets · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

A S ŠojatClinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Dr Subotica 13, 11000, Belgrade, Serbia.ORCID http://orcid.org/0000-0003-0048-1265
B Dunjić-KostićFaculty of Medicine, University of Belgrade, Dr Subotica 8, 11000, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-7373-2515
L V MarinaClinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Dr Subotica 13, 11000, Belgrade, Serbia. ljilja.marina@gmail.com.ORCID http://orcid.org/0000-0003-2664-3664
M IvovićClinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Dr Subotica 13, 11000, Belgrade, Serbia.ORCID http://orcid.org/0000-0001-5807-2240
N V RadonjićDepartment of Psychiatry, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA.ORCID http://orcid.org/0000-0002-1272-2284
A KendereškiClinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Dr Subotica 13, 11000, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-3019-7006
A ĆirkovićFaculty of Medicine, University of Belgrade, Dr Subotica 8, 11000, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-7542-5690
M Tančić-GajićClinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Dr Subotica 13, 11000, Belgrade, Serbia.ORCID http://orcid.org/0000-0001-7290-5181
Z ArizanovićClinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Dr Subotica 13, 11000, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-0329-3094
S MihajlovićFaculty of Medicine, University of Belgrade, Dr Subotica 8, 11000, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-9013-0401
S VujovićClinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Dr Subotica 13, 11000, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-9353-5367
University of Belgrade · RSCenter for Health, Exercise and Sport Sciences · RSSUNY Upstate Medical University · US

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (RS) 175067
6 · The paper itself

Abstract

purposeHypercortisolism is associated with a high prevalence of depression and impaired health-related quality of life (QoL). According to the available literature, studies examining the depression risk in patients with adrenal incidentalomas (AI), nonfunctioning and the ones with (possible) autonomous cortisol secretion ((P)ACS) are scarce. The aim of this observational, case-control study was to screen patients with nonfunctioning adrenal incidentalomas (NAI) and the ones with (P)ACS for depression and to assess their QoL.

methodsThe total studied group consisted of 92 subjects-26 with NAI, 34 with (P)ACS and 32 age-matched healthy controls (HC). To screen for depression, we used the Beck Depression Inventory-II (BDI-II) and to assess the QoL, we used the Short-Form 36 Health Survey (SF-36).

resultsPatients with (P)ACS had significantly higher BDI-II scores and substantially lower QoL than patients with NAI or HC. Midnight cortisol level was the most significant predictor of BDI-II and SF-36 score. The receiver operating characteristic curve analysis demonstrated that a midnight cortisol value of 86.95 nmol/l had a high sensitivity (82.8%) and high specificity (80%) for detection of mild depression in patients with (P)ACS.

conclusionScreening for depression and QoL assessment should become an integral part of clinical evaluation in patients with (P)ACS.

Indexed as

Adrenal Cortex NeoplasmsAdrenal Gland NeoplasmsAdultAgedCase-Control StudiesDepressionFemaleHealth StatusHumansHydrocortisoneIncidental FindingsMaleMass ScreeningMiddle AgedPrevalencePsychiatric Status Rating ScalesHydrocortisoneAdrenal incidentalomaBDI-IIDepression screeningNonfunctioning adrenal incidentaloma(possible) autonomous cortisol excessQuality of life

Identifiers

PMID33528757
OpenAlexW3126207561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.