Evidence map›Paper›PMID 33528749›Full record

ArticleInternational journal of colorectal disease2021

Prognostic factors for stage III colon cancer in patients 80 years of age and older.

Bogdan Badic, Maude Oguer, Melanie Cariou, Tiphaine Kermarrec, Servane Bouzeloc, Jean-Baptiste Nousbaum, Michel Robaszkiewicz, Lucille Queneherve

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in International journal of colorectal disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04526314 (Treatment and Outcomes of Stage III Colon Cancer in Patients 80 Years of Age and Older), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04526314 completednot on this map

Treatment and Outcomes of Stage III Colon Cancer in Patients 80 Years of Age and Older

TypeobservationalSponsorRegistre des Tumeurs Digestives du FinistèreRan2018 to 2020Enrolled308ConditionsColon AdenocarcinomaArmsobservational
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bogdan BadicCHRU Brest, Service de Chirurgie Viscérale, Brest, France. bogdan.badic@chu-brest.fr.ORCID http://orcid.org/0000-0003-4608-8960
Maude OguerCHRU Brest, Service de Chirurgie Viscérale, Brest, France.
Melanie CariouRegistre des Cancers Digestifs du Finistère, Brest, France.
Tiphaine KermarrecRegistre des Cancers Digestifs du Finistère, Brest, France.
Servane BouzelocRegistre des Cancers Digestifs du Finistère, Brest, France.
Jean-Baptiste NousbaumRegistre des Cancers Digestifs du Finistère, Brest, France.
Michel RobaszkiewiczRegistre des Cancers Digestifs du Finistère, Brest, France.
Lucille QueneherveRegistre des Cancers Digestifs du Finistère, Brest, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOncological strategies in the elderly population are debated. The objective of this study was to assess the factors predictive of poor prognosis in elderly patients with stage III colon cancer.

methodsA retrospective review of demographic, pathologic, treatment, and outcome data from 308 patients with stage III colon adenocarcinoma who had undergone surgery between 2007 and 2014 was conducted. A proportional hazards model was used to assess the association of prognostic factors with disease-free survival (DFS) and overall survival (OS).

resultsThe 5-year survival rate was 34.4% (95% CI 27.1-39.8%) and Charlson comorbidity index was a significant predictor of death (p < 0.01). The presence of perineural invasion (p = 0.03) and incomplete resection (p < 0.001) were significantly correlated with OS. The postoperative (30 days) mortality rate was 11.7%. Adjuvant chemotherapy was significantly associated with better OS (p < 0.001) independently of the regimens. Disease-free survival was significantly correlated with adjuvant chemotherapy (HR 0.63, 95% CI: 0.42-0.97, p = 0.034), Charlson comorbidity index (CCI 5; HR 1.61, 95% CI: 1.05-2.48, p = 0.029), and venous and/or perineural invasion (HR 1.54, 95% CI: 1.03-2.29, p = 0.035).

conclusionAge, comorbidities, tumor histology, and adjuvant chemotherapy were independent predictors of prognosis in patients with stage III colon cancer. These data can be used to identify elderly patients with poor prognosis and to design future tailored randomized clinical trials.

trial registrationClinicalTrial.gov No. NCT04526314. Date of registration 25 August 2020.

Indexed as

Colonic NeoplasmsAgedChemotherapy, AdjuvantDisease-Free SurvivalHumansNeoplasm StagingPrognosisRetrospective StudiesChemotherapyElderlyStage III colon cancerSurgerySurvival

Identifiers

PMID33528749

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.