Evidence map›Paper›PMID 33528726›Full record

ArticleInflammation2021

CQMUH-011 Inhibits LPS-Induced Microglia Activation and Ameliorates Brain Ischemic Injury in Mice.

Hailin Liu, Xiangnan Hu, Rong Jiang, Jianghui Cai, Qiao Lin, Zhiguo Fan, Pan Zhao, Song Wang, Chunqiao Zou, Weimin Du and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. The Autism Spectrum Disorder-Associated Bacterial MetaboliteInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Hailin LiuDepartment of Pharmacology, the Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, 400016, China.
Xiangnan HuDepartment of Pharmacology, the Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, 400016, China.
Rong JiangCollege of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.
Jianghui CaiDepartment of Pharmacology, the Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, 400016, China.
Qiao LinDepartment of Pharmacology, the Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, 400016, China.
Zhiguo FanDepartment of Pharmacy, First People's Hospital of Chongqing Liangjiang New zone, Chongqing, 401121, China.
Pan ZhaoDepartment of Pharmacy, First People's Hospital of Chongqing Liangjiang New zone, Chongqing, 401121, China.
Song WangDepartment of Pharmacy, First People's Hospital of Chongqing Liangjiang New zone, Chongqing, 401121, China.
Chunqiao ZouDepartment of Pharmacy, First People's Hospital of Chongqing Liangjiang New zone, Chongqing, 401121, China.
Weimin DuDepartment of Pharmacology, the Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, 400016, China.
Zhi DongDepartment of Pharmacology, the Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, 400016, China.
Yingju LiuDepartment of Pharmacology, the Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, 400016, China. liuyingju@cqmu.edu.cn.ORCID http://orcid.org/0000-0001-8784-9717
Chongqing Medical University · CNFirst People's Hospital of Chongqing · CN

Funding

Chongqing Municipal Health Bureau 2014-2-223Chongqing Science and Technology Commission cstc2015zdcy-ztzx120003Chongqing Science and Technology Commission cstc2019jscx-msxmX0096
6 · The paper itself

Abstract

Excessive microglial activation-mediated neuroinflammation is closely involved in the pathogenesis of several neurological diseases. CQMUH-011, as a novel adamantane sulfonamide compound, has been shown anti-inflammatory properties in activated macrophages (RAW264.7). However, the role of CQMUH-011 in microglial activation-induced neuroinflammation and neuroprotective properties has yet to be elucidated. In the present study, we investigated the potential effects and mechanisms of CQMUH-011 on lipopolysaccharide (LPS)-stimulated primary microglia in vitro and transient middle cerebral artery occlusion (t-MCAO)-induced acute cerebral ischemia/reperfusion (I/R) injury in vivo. The results demonstrated that CQMUH-011 significantly suppressed the production of tumor necrosis factor (TNF)-α and interleukin (IL)-1β by LPS-stimulated primary microglia. In addition, CQMUH-011 inhibited the proliferation of activated microglia by arresting the cell cycle at the G

Indexed as

AnimalsAnti-Inflammatory AgentsBrain IschemiaCells, CulturedDose-Response Relationship, DrugInflammation MediatorsLipopolysaccharidesMaleMiceMice, Inbred C57BLMicrogliaReperfusion InjuryAnti-Inflammatory AgentsInflammation MediatorsLipopolysaccharidescerebral ischemia/reperfusion injureCQMUH-011MAPKsmicroglianeuroinflammationNF-κB

Identifiers

PMID33528726
PMCPMC8285337
OpenAlexW3128560382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.