Evidence map›Paper›PMID 33528667›Full record

ArticleSurgical endoscopy2022

Antireflux surgery leads to durable improvement in laryngopharyngeal reflux symptoms.

Lindsay K Hessler, Yiwei Xu, Amber L Shada, Morgan K Johnson, Luke M Funk, Jacob A Greenberg, Anne O Lidor

Abstract read
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In one paragraph

Article in Surgical endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lindsay K HesslerDepartment of Surgery, Division of Minimally Invasive and Bariatric Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue K4/752, Madison, WI, 53792-7375, USA.
Yiwei XuDepartment of Surgery, Division of Minimally Invasive and Bariatric Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue K4/752, Madison, WI, 53792-7375, USA.
Amber L ShadaDepartment of Surgery, Division of Minimally Invasive and Bariatric Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue K4/752, Madison, WI, 53792-7375, USA.
Morgan K JohnsonDepartment of Surgery, Division of Minimally Invasive and Bariatric Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue K4/752, Madison, WI, 53792-7375, USA.
Luke M FunkDepartment of Surgery, Division of Minimally Invasive and Bariatric Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue K4/752, Madison, WI, 53792-7375, USA.
Jacob A GreenbergDepartment of Surgery, Division of Minimally Invasive and Bariatric Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue K4/752, Madison, WI, 53792-7375, USA.
Anne O LidorDepartment of Surgery, Division of Minimally Invasive and Bariatric Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue K4/752, Madison, WI, 53792-7375, USA. lidor@surgery.wisc.edu.ORCID 0000-0002-9911-3114
University of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLaryngopharyngeal reflux (LPR) symptoms are often present in patients with Gastroesophageal reflux disease (GERD). Whereas antireflux surgery (ARS) provides predictably excellent results in patients with typical GERD, those with atypical symptoms have variable outcomes. The goal of this study was to characterize the response of LPR symptoms to antireflux surgery.

methodsPatients who underwent ARS between January 2009 and May 2020 were prospectively identified from a single institutional database. Patient-reported information on LPR symptoms was collected at standardized time points (preoperative and 2 weeks, 8 weeks, and 1 year postoperatively) using a validated Reflux Symptom Index (RSI) questionnaire. Patients were grouped by preoperative RSI score: ≤ 13 (normal) and > 13 (abnormal). Baseline characteristics were compared between groups using chi-square test or t-test. A mixed effects model was used to evaluate improvement in RSI scores.

resultsOne hundred and seventy-six patients fulfilled inclusion criteria (mean age 57.8 years, 70% female, mean BMI 29.4). Patients with a preoperative RSI ≤ 13 (n = 61) and RSI > 13 (n = 115) were similar in age, BMI, primary reason for evaluation, DeMeester score, presence of esophagitis, and hiatal hernia (p > 0.05). The RSI > 13 group had more female patients (80 vs 52%, p = < 0.001), higher mean GERD-HRQL score, lower rates of PPI use, and normal esophageal motility. The RSI of all patients improved from a mean preoperative value of 19.2 to 7.8 (2 weeks), 6.1 (8 weeks), and 10.9 (1 year). Those with the highest preoperative scores (RSI > 30) had the best response to ARS. When analyzing individual symptoms, the most likely to improve included heartburn, hoarseness, and choking.

conclusionsIn our study population, patients with LPR symptoms achieved a rapid and durable response to antireflux surgery. Those with higher preoperative RSI scores experienced the greatest improvement. Our data suggest that antireflux surgery is a viable treatment option for this patient population.

Indexed as

Esophagitis, PepticHernia, HiatalLaryngopharyngeal RefluxFemaleFundoplicationHumansMaleMiddle AgedTreatment OutcomeAntireflux surgeryAtypical GERDLaryngopharyngeal reflux

Identifiers

PMID33528667
OpenAlexW3128960674

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.