Evidence map›Paper›PMID 33528632›Full record

ArticleInternational orthopaedics2021

Cemented stems in healthy elderly patients result in higher hypoxia despite a paradoxical lower femoral increase of intramedullary pressure.

Skender Ukaj, Matjaž Veslko, Shaip Krasniqi, Vlora Podvorica, Fatime Ukaj, Arben Ahmeti, Philippe Hernigou, Matej Cimerman

Registry-linked trialAbstract read
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In one paragraph

Article in International orthopaedics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03930537 (DIfference of Femoral Intramedullar Pressure After Implantation of Cemented Versus Non-cemented Femoral Component of Hip Prothesis), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03930537 nacompletednot on this map

DIfference of Femoral Intramedullar Pressure After Implantation of Cemented Versus Non-cemented Femoral Component of Hip Prothesis

TypeinterventionalSponsorUniversity Clinical Centre of KosovaRan2019 to 2019Enrolled60ConditionsArthroplasty ComplicationsArmsHip replacement
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Bone cement implantation syndrome: a scoping review.British journal of anaesthesia · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Skender UkajUniversity of Ljubljana, Ljubljana, Slovenia.
Matjaž VeslkoUniversity of Ljubljana, Ljubljana, Slovenia.
Shaip KrasniqiFaculty of Medicine, University of Prishtina, Prishtina, Kosovo.
Vlora PodvoricaOrthopaedic and Traumatology Department, University Clinical Center of Prishtina, Prishtina, Kosovo.
Fatime UkajNational Institute of Public Health, Prishtina, Kosovo.
Arben AhmetiOrthopaedic and Traumatology Department, University Clinical Center of Prishtina, Prishtina, Kosovo.
Philippe HernigouUniversité Paris Est, Paris, France. philippe.hernigou@wanadoo.fr.ORCID http://orcid.org/0000-0002-8475-279X
Matej CimermanUniversity of Ljubljana, Ljubljana, Slovenia.
University of Ljubljana · SIUniversity Clinical Center of Kosovo · XKUniversity of Prishtina · XKParis-Est Sup · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHypoxia is a well-known complication in cemented arthroplasty; however, it is not known whether the level of hypoxia is related to the intramedullary pressure or to the age of the patient; therefore, we studied the intramedullary pressure and level of hypoxia in patients undergoing cemented arthroplasty.

methodsA prospective study was performed during cemented arthroplasties in 25 patients with an average age of 66.2 ± 12.1 years old. The intramedullary pressure (IMP) was measured by placing a pressure transducer within the bone while simultaneously measuring the pulse oximetry arterial oxygen saturation (SpO2), pulse, and blood pressure. These variables were obtained immediately after spinal anaesthesia, five minutes after cementation, and 15 minutes after prosthesis insertion.

resultsOne hundred percent of patients had hypoxia at some level, but 83% of elderly patients (older than 66.5 years) had hypoxia (SpO2 <94%) as compared to only 23% of younger patients (p = 0.006). In the group of young patients, IMP was roughly increased 32 times as compared with baseline level, with as consequences a decrease of 4% of SpO2 (from 98.3 to 94.15%); in the elderly group, the IMP was only increased 20 times, but a decrease of 6% of SpO2 (from 97.25 to 91%) was observed.

conclusionsThis series demonstrated higher hypoxia in elderly healthy patients despite a paradoxical lower femoral increase of intramedullary pressure as compared with younger patients. This hypoxia is probably not only related to the cement but also to the patient's age with decline of maximum oxygen uptake capacity and increase bone porosity. CLINICAL TRIALS: ClinicalTrials.gov Identifier: NCT03930537 https://clinicaltrials.gov/ct2/show/NCT03930537.

Indexed as

Arthroplasty, Replacement, HipHip ProsthesisAgedBone CementsCementationHumansHypoxiaMiddle AgedOxygenOxygen ConsumptionProspective StudiesBone CementsOxygenBone porosityCement and hypoxiaCemented arthroplastyCemented stemsIntramedullary pressureOxygen uptake

Identifiers

PMID33528632
OpenAlexW3128383845

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.