ArticleIntensive care medicine2021
Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19.
Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
In one paragraph
Article in Intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04343898 (Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19), which is not on this map. Cited by 109 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 3 pooled it
19.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19
Who cites it
109 citing papers in PubMed, 3 syntheses or guidelines pooled it, 249 citations in OpenAlex.
- Intracranial hemorrhage in patients treated for SARS-CoV-2 with extracorporeal membrane oxygenation: A systematic review and meta-analysis.Journal of critical care · 2023Pooled it
- Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials: A Systematic Review.JAMA network open · 2023Pooled it
- Evolution of Acute Respiratory Distress Syndrome in Emergency and Critical Care: Therapeutic Management before and during the Pandemic Situation.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Association between preoperative vasoactive inotropic score and clinical outcomes in severe pneumonia patients with sepsis undergoing extracorporeal membrane oxygenation: an analysis from the Chinese Society of ExtraCorporeal Life Support (CSECLS) Registry.European journal of medical research · 2026Article
- Healthcare professionals' views on training, standards, and resources for extracorporeal membrane oxygenation: a cross-sectional survey.Croatian medical journal · 2026Article
- Comparative Prognostic Performance of SOFA2.0 and SOFA for 28-Day Mortality in Patients Developing Sepsis During ECMO Support.Journal of inflammation research · 2026Article
- The Impact of Venovenous Extracorporeal Membrane Oxygenation Cannulation Configuration on Hemodynamic Characteristics and Risks of Hemolysis.Annals of biomedical engineering · 2025Article
- Review
- The dual threat: exploring the emergence of human metapneumovirus and SARS-CoV-2 coinfections in respiratory infections.3 Biotech · 2025Review
- Effect of Structural Changes in Extracorporeal Membrane Oxygenation Return Cannulas on Hemodynamic Performance and Blood Damage Associated with Cannulation.Annals of biomedical engineering · 2025Article
- Evaluating Predictive Value of Plasma Free Hemoglobin (PFH) in ECMO for COVID-19, Non-COVID-19 Pulmonary, and Cardiac Patients.Medicina (Kaunas, Lithuania) · 2025Article
- Article
- Characteristics of Bleeding Complications in Patients with Severe COVID-19 Requiring Veno-venous Extracorporeal Membrane Oxygenation in Japan.Thrombosis and haemostasis · 2025Observational
- Use of machine learning models to predict mechanical ventilation, ECMO, and mortality in COVID-19.Frontiers in artificial intelligence · 2025Article
- The use of extracorporeal membrane oxygenation in COVID-19: a systematic review.Archives of medical science : AMS · 2025Review
- In COVID-19 Patients Supported with Extracorporeal Membrane Oxygenation, Intensive Care Unit Mortality Is Associated with the Blood Transfusion Rate.Journal of clinical medicine · 2024Article
- Use of Extracorporeal Membrane Oxygenation for Patients with Coronavirus Disease 2019 Infection.Advances in surgery · 2024Review
- ECMO is associated with decreased hospital mortality in COVID-19 ARDS.Scientific reports · 2024Article
- Effect of immediate initiation of invasive ventilation on mortality in acute hypoxemic respiratory failure: a target trial emulation.Critical care (London, England) · 2024Article
- Status of COVID-19 Patients Treated With Extracorporeal Membrane Oxygenation in Japan: Nationwide Database Analysis.Cureus · 2024Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 11 institutions in 1 country.
Shahzad Shaefi *Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 1 Deaconess Road, Boston, MA, 02215, USA. sshaefi@bidmc.harvard.edu.ORCID http://orcid.org/0000-0002-6832-3282
Samantha K Brenner *Department of Internal Medicine, Hackensack Meridian School of Medicine at Seton Hall, Nutley, NJ, USA.
Shruti Gupta *Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Brian P O'GaraDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 1 Deaconess Road, Boston, MA, 02215, USA.
Megan L KrajewskiDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 1 Deaconess Road, Boston, MA, 02215, USA.
David M CharytanDivision of Nephrology, New York University Grossman School of Medicine, New York, NY, USA.
Sobaata ChaudhryDivision of Nephrology, New York University Grossman School of Medicine, New York, NY, USA.
Sara H MirzaDivision of Pulmonary and Critical Care Medicine, Rush University Medical Center, Chicago, IL, USA.
Vasil PeevDepartment of Medicine, Rush University Medical Center, Chicago, IL, USA.
Mark AndersonDepartment of Surgery, Hackensack Meridian School of Medicine at Seton Hall, Nutley, NJ, USA.
Anip BansalDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Salim S HayekDivision of Cardiology, Department of Medicine, University of Michigan, Ann Arbor, MI, USA.
Anand SrivastavaDivision of Nephrology and Hypertension, Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Kusum S MathewsDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tanya S JohnsDivision of Nephrology, Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, The Bronx, NY, USA.
Amanda Leonberg-YooRenal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Adam GreenDivision of Critical Care Medicine, Cooper University Health Care, Camden, NJ, USA.
Justin ArunthamakunDepartment of Internal Medicine, Baylor University Medical Center, Baylor Research Institute, Dallas, TX, USA.
Keith M WilleDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Tanveer ShaukatDivision of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Harkarandeep SinghDivision of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Andrew J AdmonDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Matthew W SemlerDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Miguel A HernánDepartments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Ariel L Mueller *Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.
Wei Wang *Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
David E Leaf *Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA.
STOP-COVID Investigators
Brigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USRush University Medical Center · USAlbert Einstein College of Medicine · USBaylor University Medical Center · USHarvard University · USNorthwestern University · USUniversity of Michigan · USCooper University Health Care · USHackensack University Medical Center · USNew York University · US
Funding
Dynamic Strategies for the clinical management of HIV diseaseR37AI102634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI MIGUEL HERNAN · 2018 to 2026
$5.3MDeferoxamine for the Prevention of Acute Kidney InjuryR01DK125786 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI LEAF, DAVID EVAN · 2020 to 2024
$3.5MRole of SuPAR in the Intersection between Cardiovascular and Kidney DiseaseR01HL153384 · NHLBI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HAYEK, SALIM · 2020 to 2024
$2.5MPrecision Medicine Approach to Vitamin D3 Administration in Critical IllnessR01HL144566 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEAF, DAVID EVAN · 2019 to 2022
$1.8MThe Assessment of Acute Kidney Injury Sub-phenotypes in the Intensive Care UnitK23DK116967 · NIDDK · UNIVERSITY OF WASHINGTON · PI BHATRAJU, PAVAN KUMAR · 2019 to 2023
$938kOxygen Saturation Targets during Mechanical Ventilation of Critically Ill Adults: A Clinical TrialK23HL143053 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SEMLER, MATTHEW WALL · 2018 to 2022
$854kSepsis and the benefits of permissive hypoxiaK08GM134220 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAEFI, SHAHZAD · 2019 to 2022
$775kDiet Related Inflammation and Kidney Function Decline in Racial/Ethnic MinoritiesK23DK124644 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI JOHNS, TANYA · 2021 to 2023
$752kOptimizing ED to ICU triage decisions for critically ill patients in respiratory distressK23HL130648 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MATHEWS, KUSUM SARA · 2016 to 2021
$744kExtracorporeal SuPAR Extraction to Prevent COVID-19-associated Acute Kidney InjuryR01DK128012 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAYEK, SALIM · 2021 to 2021
$327kProteomic Analysis of Postoperative Delirium from a randomized trial in Older Patients undergoing Cardiac Surgery exposed to Intraoperative Normoxia versus Hyperoxia: A Nested Case-Control StudyR03AG060179 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAEFI, SHAHZAD · 2018 to 2019
$263kChronic kidney disease as a risk factor for incident hearing lossF32DC017342 · NIDCD · BRIGHAM AND WOMEN'S HOSPITAL · PI GUPTA, SHRUTI · 2018 to 2019
$167kNHLBI NIH HHS K23 HL130648NHLBI NIH HHS K23 HL143053NHLBI NIH HHS R01 HL144566NHLBI NIH HHS R01 HL153384NIAID NIH HHS R37 AI102634NIA NIH HHS R03 AG060179NIDCD NIH HHS F32 DC017342NIDDK NIH HHS K23 DK116967NIDDK NIH HHS K23 DK124644NIDDK NIH HHS L60 DK126281NIDDK NIH HHS R01 DK125786NIDDK NIH HHS R01 DK128012NIGMS NIH HHS K08 GM134220
Abstract
purposeLimited data are available on venovenous extracorporeal membrane oxygenation (ECMO) in patients with severe hypoxemic respiratory failure from coronavirus disease 2019 (COVID-19).
methodsWe examined the clinical features and outcomes of 190 patients treated with ECMO within 14 days of ICU admission, using data from a multicenter cohort study of 5122 critically ill adults with COVID-19 admitted to 68 hospitals across the United States. To estimate the effect of ECMO on mortality, we emulated a target trial of ECMO receipt versus no ECMO receipt within 7 days of ICU admission among mechanically ventilated patients with severe hypoxemia (PaO
resultsAmong the 190 patients treated with ECMO, the median age was 49 years (IQR 41-58), 137 (72.1%) were men, and the median PaO
conclusionIn select patients with severe respiratory failure from COVID-19, ECMO may reduce mortality.
Indexed as
Extracorporeal Membrane OxygenationAdultCohort StudiesCOVID-19FemaleHumansMaleMiddle AgedRespiratory Distress SyndromeTreatment OutcomeARDSCOVID-19Extracorporeal membrane oxygenationMortalitySevere respiratory failureVV-ECMO
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
NCT04343898ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.