ArticleOptics letters2021
Speckle illumination SFDI for projector-free optical property mapping.
Article in Optics letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Multi-contrast laser endoscopy for in vivo gastrointestinal imaging.Npj imaging · 2026Article
- Assessing the micromechanical architecture of joint tissues with speckle rheological microscopy.Nature communications · 2026Article
- Structured light radial-view endoscope PROBE for IMAGING of colorectal tissue.Optics letters · 2025Article
- Speckle-illumination spatial frequency domain imaging with a stereo laparoscope for profile-corrected optical property mapping.Journal of biomedical optics · 2025Article
- Ultra-miniature dual-wavelength spatial frequency domain imaging for micro-endoscopy.Journal of biomedical optics · 2024Article
- Quantitative hemodynamic imaging: a method to correct the effects of optical properties on laser speckle imaging.Neurophotonics · 2023Article
- Designing and simulating realistic spatial frequency domain imaging systems using open-source 3D rendering software.Biomedical optics express · 2023Article
- Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms.Materials (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Spatial frequency domain imaging can map tissue scattering and absorption properties over a wide field of view, making it useful for clinical applications such as wound assessment and surgical guidance. This technique has previously required the projection of fully characterized illumination patterns. Here, we show that random and unknown speckle illumination can be used to sample the modulation transfer function of tissues at known spatial frequencies, allowing the quantitative mapping of optical properties with simple laser diode illumination. We compute low- and high-spatial frequency response parameters from the local power spectral density for each pixel and use a lookup table to accurately estimate absorption and scattering coefficients in tissue phantoms, in vivo human hand, and ex vivo swine esophagus. Because speckle patterns can be generated over a large depth of field and field of view with simple coherent illumination, this approach may enable optical property mapping in new form-factors and applications, including endoscopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.