Evidence map›Paper›PMID 33528320›Full record

ArticleAJOB neuroscience2021

A Qualitative Analysis of Ethical Perspectives on Recruitment and Consent for Human Intracranial Electrophysiology Studies.

Joncarmen V Mergenthaler, Winston Chiong, Daniel Dohan, Josh Feler, Cailin R Lechner, Philip A Starr, Jalayne J Arias

Open access · greenAbstract read
In one paragraph

Article in AJOB neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Engaging patient communities in intracranial neuroscience research.medRxiv : the preprint server for health sciences · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joncarmen V MergenthalerUniversity of California.
Winston ChiongUniversity of California.ORCID 0000-0001-9188-1920
Daniel DohanUniversity of California.
Josh FelerYale University.
Cailin R LechnerUniversity of California.
Philip A StarrUniversity of California.
Jalayne J AriasUniversity of California.
University of California System · USYale University · US

Funding

The motor network in Parkinson's disease: Mechanisms of therapyR01NS090913 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STARR, PHILIP ANDREW · 2014 to 2023
$3.3M
Achieving ethical integration in the development of novel neurotechnologiesR01MH114860 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIONG, WINSTON, DOHAN, DANIEL P. · 2017 to 2020
$2.0M
Employment and Insurance Discrimination Based on Biomarkers for Alzheimer's diseaseK01AG057796 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARIAS, JALAYNE J · 2018 to 2022
$652k
NIA NIH HHS K01 AG057796NIMH NIH HHS R01 MH114860NINDS NIH HHS R01 NS090913
6 · The paper itself

Abstract

Intracranial electrophysiological research methods, including those applying electrodes on the cortical surface or in deep structures, have become increasingly important in human neuroscience. They also pose novel ethical concerns, as human studies require the participation of neurological patients undergoing surgery for conditions such as epilepsy and Parkinson's disease. Research participants in this setting may be vulnerable to conflicts of interest, therapeutic misconception, and other threats to valid recruitment and consent. We conducted semi-structured interviews with investigators from NIH-funded studies involving recording or stimulation inside the human skull. We elicited perspectives on study recruitment and consent procedures, and analyzed transcripts using a modified grounded theory approach. We interviewed 26 investigators from 19 separate intracranial electrophysiology studies, who described two study types: opportunity studies (

Indexed as

ElectrophysiologyInformed ConsentTherapeutic MisconceptionBrainHumansResearch DesignResearch PersonnelInformed consentneuroethicsneurosurgeryresearch

Identifiers

PMID33528320
PMCPMC8168380
OpenAlexW3128494325

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.