Evidence map›Paper›PMID 33527997›Full record

ArticleBiostatistics (Oxford, England)2022

Treed distributed lag nonlinear models.

Daniel Mork, Ander Wilson

Abstract read
In one paragraph

Article in Biostatistics (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Multi-Tree Model for Precision Environmental Health with Longitudinally Assessed Mixture Exposure.Journal of the Royal Statistical Society. Series C, Applied statistics · 2026
    Article
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  5. Review
  6. A novel approach for inferring effects on pregnancy loss.American journal of epidemiology · 2025
    Article
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  9. Article
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniel MorkStatistics Department, Colorado State University, 1877 Campus Delivery, Fort Collins, CO, USA 80523.ORCID 0000-0002-7924-0706
Ander WilsonStatistics Department, Colorado State University, 1877 Campus Delivery, Fort Collins, CO, USA 80523.ORCID 0000-0003-4774-3883

Funding

Methods for Data Integration and Risk Assessment for Environmental MixturesR01ES028811 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI COULL, BRENT ANDREW, GENNINGS, CHRIS · 2018 to 2021
$1.9M
NIEHS NIH HHS R01 ES028811
6 · The paper itself

Abstract

In studies of maternal exposure to air pollution, a children's health outcome is regressed on exposures observed during pregnancy. The distributed lag nonlinear model (DLNM) is a statistical method commonly implemented to estimate an exposure-time-response function when it is postulated the exposure effect is nonlinear. Previous implementations of the DLNM estimate an exposure-time-response surface parameterized with a bivariate basis expansion. However, basis functions such as splines assume smoothness across the entire exposure-time-response surface, which may be unrealistic in settings where the exposure is associated with the outcome only in a specific time window. We propose a framework for estimating the DLNM based on Bayesian additive regression trees. Our method operates using a set of regression trees that each assume piecewise constant relationships across the exposure-time space. In a simulation, we show that our model outperforms spline-based models when the exposure-time surface is not smooth, while both methods perform similarly in settings where the true surface is smooth. Importantly, the proposed approach is lower variance and more precisely identifies critical windows during which exposure is associated with a future health outcome. We apply our method to estimate the association between maternal exposures to PM$_{2.5}$ and birth weight in a Colorado, USA birth cohort.

Indexed as

Air PollutantsAir PollutionBayes TheoremChildFemaleHumansMaternal ExposureNonlinear DynamicsParticulate MatterPregnancyAir PollutantsParticulate MatterAir pollutionChildren’s healthCritical windowsDistributed lagRegression trees

Identifiers

PMID33527997
PMCPMC9293054

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.