Evidence map›Paper›PMID 33527979›Full record

ArticleAmerican journal of clinical pathology2021

Clinicopathologic Features of Peripheral T-Cell Lymphoma in Sub-Saharan Africa.

Megan J Fitzpatrick, Shahin Sayed, Zahir Moloo, Mukendi K A Kayembe, Drucilla J Roberts, Thu-Anh Pham, Liqiang Xi, Mark Raffeld, Abner Louissaint, Aliyah R Sohani

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of clinical pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Megan J FitzpatrickDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9336-1865
Shahin SayedDepartment of Pathology, Aga Khan University Hospital, Nairobi, Kenya.
Zahir MolooDepartment of Pathology, Aga Khan University Hospital, Nairobi, Kenya.
Mukendi K A KayembeBotswana National Health Laboratory, Gaborone, Botswana.
Drucilla J RobertsDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Thu-Anh PhamDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Liqiang XiLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Mark RaffeldLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Abner LouissaintDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Aliyah R SohaniDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Harvard University · USAga Khan University Hospital Nairobi · KENational Institutes of Health · US

Funding

Molecular Diagnostics Core LaboratoryZICBC011079 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI XI, LIQIANG · 2009 to 2025
$33.8M
6 · The paper itself

Abstract

objectivesPeripheral T-cell lymphomas (PTCLs) are heterogeneous, clinically aggressive, and rare. Subtype distribution varies by geographic location; however, data from sub-Saharan Africa (SSA) are lacking. We sought to elucidate clinicopathologic features of PTCL in SSA.

methodsWe reviewed PTCL consultation cases from three SSA countries. PTCL subtype was determined per 2017 World Health Organization classification. Cases with sufficient material were evaluated by polymerase chain reaction for human T-cell leukemia virus type 1 (HTLV-1) and T-cell receptor γ (TCRG) rearrangement.

resultsAmong 32 cases, median age was 45 years and male-to-female ratio was 1.7. Thirty (94%) of 32 cases required additional workup for subclassification. PTCL, not otherwise specified (PTCL-NOS) was the most common subtype (13/32, 41%), followed by PTCL with T-follicular helper phenotype (6/32, 19%) and systemic anaplastic large cell lymphoma (6/32, 19%). Four (16%) of 25 cases were Epstein-Barr virus positive (EBV+) (2/2 extranodal natural killer/T-cell lymphoma, 1/13 PTCL-NOS, and 1/4 angioimmunoblastic T-cell lymphoma with EBV+ immunoblasts). Two (15%) of 13 patients with PTCL-NOS were human immunodeficiency virus positive. No cases with evaluable DNA (0/15) were HTLV-1 positive, and 9 of 10 showed clonal TCRG rearrangements.

conclusionsIn comparison to Western studies, PTCLs from SSA show similar subtype distribution and male predominance but a younger age at diagnosis. Appropriate diagnosis of PTCL requires extensive ancillary testing not readily available in low-income countries, including much of SSA.

Indexed as

AdultAfrica South of the SaharaAgedFemaleHumansLymphoma, T-Cell, PeripheralMaleMiddle AgedEpstein-Barr virusLow/middle-income countriesPeripheral T-cell lymphomaSub-Saharan Africa

Identifiers

PMID33527979
PMCPMC8209619
OpenAlexW3126408660

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.