Evidence map›Paper›PMID 33527977›Full record

ArticleJornal brasileiro de nefrologia

BK virus nephropathy in a heart transplant recipient.

John Fredy Nieto-Ríos, Diego Armando Benavides-Henao, Arbey Aristizabal-Alzate, Carol Morales-Contreras, Diana Carolina Chacón-Jaimes, Gustavo Zuluaga-Valencia, Lina María Serna-Higuita

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Jornal brasileiro de nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Native BK Polyomavirus Nephropathy in an Orthotopic Heart Transplant Patient.Journal of investigative medicine high impact case reports
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

John Fredy Nieto-RíosHospital Pablo Tobón Uribe, Department of Nephrology and Kidney Transplant, Medellín, Colombia.ORCID http://orcid.org/0000-0003-4781-3597
Diego Armando Benavides-HenaoUniversity of Antioquia, Nephrology Section, Department of Internal Medicine, Medellin, Colombia.ORCID http://orcid.org/0000-0003-2613-9230
Arbey Aristizabal-AlzateHospital Pablo Tobón Uribe, Department of Nephrology and Kidney Transplant, Medellín, Colombia.
Carol Morales-ContrerasUniversity of Antioquia, Nephrology Section, Department of Internal Medicine, Medellin, Colombia.
Diana Carolina Chacón-JaimesUniversity of Antioquia, Nephrology Section, Department of Internal Medicine, Medellin, Colombia.ORCID http://orcid.org/0000-0001-5510-5764
Gustavo Zuluaga-ValenciaHospital Pablo Tobón Uribe, Department of Nephrology and Kidney Transplant, Medellín, Colombia.ORCID http://orcid.org/0000-0002-9067-2710
Lina María Serna-HiguitaEberhard Karls University, Institute for Clinical Epidemiology and Applied Biometrics, Tuebingen, Germany.ORCID http://orcid.org/0000-0001-5182-8295
NHS Blood and Transplant · GBUniversidad de Antioquia · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BK virus nephropathy in kidney transplantation is widely recognized as an important cause of graft dysfunction and loss. In the case of transplants of organs other than kidney, BK virus nephropathy in native kidneys has been recognized as a cause of chronic kidney disease, which is related with immunosuppression; however, the diagnosis is usually late because the renal dysfunction is attributed to other causes, such as toxicity by anticalcineurinic drugs, interstitial nephritis due to medications, hemodynamic changes, diabetes, hypertension, etc. We report a case of BK virus nephropathy in a patient who underwent heart transplantation due to peripartum cardiomyopathy. The kidney biopsy reported active chronic tubulointerstitial nephritis associated with late stage polyomavirus nephritis and the blood viral load for BK virus was positive (logarithm 4.5). The immunosuppressive treatment was reduced, and after two years of follow-up, the patient had stable renal function with a serum creatinine of 2.5 mg/dL (GFR of 23.4 mL/min/1.73m2). We recommend that the BK virus be considered as a cause of renal dysfunction in heart transplant recipients, with the aim of detecting its replication in time to reduce immunosuppressive therapy before irreversible compromise of renal function may manifest.

Indexed as

BK VirusHeart TransplantationNephritis, InterstitialPolyomavirus InfectionsTumor Virus InfectionsHumansImmunosuppressive AgentsImmunosuppressive Agents

Identifiers

PMID33527977
PMCPMC8428640
OpenAlexW3125154405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.