Evidence map›Paper›PMID 33527895›Full record

ArticleeLife2021

Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication.

Neale J Harrison, Elizabeth Connolly, Alicia Gascón Gubieda, Zidan Yang, Benjamin Altenhein, Maria Losada Perez, Marta Moreira, Jun Sun, Alicia Hidalgo

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Insulin signaling in development.Development (Cambridge, England) · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Neale J Harrison *Structural Plasticity & Regeneration Group, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0001-6821-4089
Elizabeth Connolly *Structural Plasticity & Regeneration Group, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0002-5716-8889
Alicia Gascón GubiedaStructural Plasticity & Regeneration Group, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Zidan YangStructural Plasticity & Regeneration Group, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Benjamin AltenheinInstitute of Zoology, University of Cologne, Cologne, Germany.
Maria Losada PerezInstituto Cajal, Consejo Superior de Investigaciones Cientificas (CSIC), Madrid, Spain.
Marta MoreiraStructural Plasticity & Regeneration Group, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0002-4779-4077
Jun SunStructural Plasticity & Regeneration Group, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0002-1539-9937
Alicia HidalgoStructural Plasticity & Regeneration Group, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0001-8041-5764
University of Birmingham · GBBaylor College of Medicine · USConsejo Superior de Investigaciones Científicas · ESMax Planck Florida Institute for Neuroscience · USUniversity of Cologne · DE

Funding

Biotechnology and Biological Sciences Research Council BB/L008343/1Biotechnology and Biological Sciences Research Council BB/R00871X/1
6 · The paper itself

Abstract

Understanding how injury to the central nervous system induces de novo neurogenesis in animals would help promote regeneration in humans. Regenerative neurogenesis could originate from glia and glial neuron-glia antigen-2 (NG2) may sense injury-induced neuronal signals, but these are unknown. Here, we used

Indexed as

NeurogenesisRegenerationAnimalsAutoantibodiesCentral Nervous SystemDrosophila melanogasterDrosophila ProteinsLarvaNeural Stem CellsNeurogliaNeuronsSomatomedinsAutoantibodiesDrosophila ProteinsIlp6 protein, DrosophilaSomatomedinsdevelopmental biologydilp6D. melanogasterDrosophilaglial cellia-2injurykonneurogenesisNG2regenerationregenerative medicinestem cells

Identifiers

PMID33527895
PMCPMC7880684
OpenAlexW3127580793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.