Evidence map›Paper›PMID 33527893›Full record

ArticleeLife2021

Leptin receptor neurons in the dorsomedial hypothalamus regulate diurnal patterns of feeding, locomotion, and metabolism.

Chelsea L Faber, Jennifer D Deem, Bao Anh Phan, Tammy P Doan, Kayoko Ogimoto, Zaman Mirzadeh, Michael W Schwartz, Gregory J Morton

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A direct SCN-to-DMH output pathway organizes circadian behavioral timing.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
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  10. Review
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  12. Article
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  14. Review
  15. Article
  16. Review
  17. History and future of leptin: Discovery, regulation and signaling.Metabolism: clinical and experimental · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chelsea L FaberUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United States.ORCID 0000-0002-4812-8164
Jennifer D DeemUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United States.ORCID 0000-0002-8865-5145
Bao Anh PhanUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United States.
Tammy P DoanUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United States.
Kayoko OgimotoUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United States.
Zaman MirzadehDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, United States.
Michael W SchwartzUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United States.ORCID 0000-0003-1619-0331
Gregory J MortonUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United States.ORCID 0000-0002-8106-8386
University of Washington · USBarrow Neurological Institute · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON · 1986 to 2026
$30.4M
Diabetes, Obesity and Metabolism Training ProgramT32DK007247 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON, KRISTINA Marie UTZSCHNEIDER · 1986 to 2026
$10.0M
Novel Brain Mechanisms Controlling Glucose HomeostasisR01DK083042 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2008 to 2025
$7.6M
Nutrition, Obesity and Atherosclerosis Training ProgramT32HL007028 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1985 to 2026
$6.4M
Neuroendocrine Control of Glucose MetabolismR01DK089056 · NIDDK · UNIVERSITY OF WASHINGTON · PI MORTON, GREGORY J · 2011 to 2024
$5.6M
Thermoregulatory circuits that regulate feedingR01DK124238 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON, Tune Hannes Pers · 2020 to 2026
$3.9M
HYPOTHALAMIC NEUROCIRCUIT REMODELING TO TREAT DIABETESDP2DK128802 · NIDDK · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI MIRZADEH, ZAMAN · 2020 to 2020
$3.0M
Novel Anti-Diabetic Actions of Hypothalamic FGF19-FGFR1 SignalingR01DK101997 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2014 to 2018
$1.9M
Molecular Medicine Training ProgramT32GM095421 · NIGMS · UNIVERSITY OF WASHINGTON · PI HAWN, THOMAS R, LILES, W. CONRAD · 2011 to 2020
$1.6M
Leica SP8 WWL Confocal MicroscopeS10OD016240 · OD · UNIVERSITY OF WASHINGTON · PI CATTERALL, WILLIAM A · 2014 to 2014
$581k
Neurocircuits linking thermoregulation and feedingK01DK126793 · NIDDK · UNIVERSITY OF WASHINGTON · PI DEEM, JENNIFER DEZET · 2021 to 2022
$257k
NHLBI NIH HHS T32 HL007028NIDDK NIH HHS DP2 DK128802NIDDK NIH HHS F31 DK113673NIDDK NIH HHS K01 DK126793NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK035816NIDDK NIH HHS R01 DK083042NIDDK NIH HHS R01 DK089056NIDDK NIH HHS R01 DK101997NIDDK NIH HHS R01 DK124238NIDDK NIH HHS T32 DK007247NIGMS NIH HHS T32 GM095421NIH HHS S10 OD016240
6 · The paper itself

Abstract

The brain plays an essential role in driving daily rhythms of behavior and metabolism in harmony with environmental light-dark cycles. Within the brain, the dorsomedial hypothalamic nucleus (DMH) has been implicated in the integrative circadian control of feeding and energy homeostasis, but the underlying cell types are unknown. Here, we identify a role for DMH leptin receptor-expressing (DMH

Indexed as

Circadian RhythmAnimalsBody WeightDorsomedial Hypothalamic NucleusEnergy MetabolismFeeding BehaviorFemaleLocomotionMaleMiceObesityPhotoperiodReceptors, LeptinReceptors, Leptinchronobiologycircadian rhythmsenergy homeostasisfeedingmetabolismmouseneuroscience

Identifiers

PMID33527893
PMCPMC7880681
OpenAlexW3127967454

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.