Evidence map›Paper›PMID 33527744›Full record

ArticlePain practice : the official journal of World Institute of Pain2021

Neuropathic Pain in the Eyes, Body, and Mouth: Insights from the Sjögren's International Collaborative Clinical Alliance.

Elisabeth A Gebreegziabher, Vatinee Y Bunya, Alan N Baer, Richard C Jordan, Esen K Akpek, Jennifer Rose-Nussbaumer, Lindsey A Criswell, Caroline H Shiboski, Thomas M Lietman, John A Gonzales

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain practice : the official journal of World Institute of Pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Elisabeth A GebreegziabherFrancis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-2454-5016
Vatinee Y BunyaScheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Alan N BaerDivision of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Richard C JordanDepartment of Orofacial Sciences, School of Dentistry, University of California, San Francisco, San Francisco, California, USA.
Esen K AkpekOcular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA.
Jennifer Rose-NussbaumerFrancis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA.
Lindsey A CriswellDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Caroline H ShiboskiDepartment of Orofacial Sciences, School of Dentistry, University of California, San Francisco, San Francisco, California, USA.
Thomas M LietmanFrancis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA.
John A GonzalesFrancis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · USJohns Hopkins University · USPenn Presbyterian Medical Center · US

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAMBA, DEEPAK ASHOK · 1985 to 2024
$16.8M
Sjögren's International Collaborative Clinical Alliance Next Generation Studies (SICCA-NextGen)U01DE028891 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHIBOSKI, CAROLINE HELENE · 2020 to 2024
$4.0M
Developing new methods for early detection of Sjogren's syndromeR01EY026972 · NEI · UNIVERSITY OF PENNSYLVANIA · PI BUNYA, VATINEE Y · 2016 to 2020
$2.0M
Non-Sjogren's Syndrome-and Sjogren's Syndrome-related Keratoconjunctivitis SICCA: A Spectrum of Inflammatory Dry EyeK23EY026998 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GONZALES, JOHN ALEXANDER · 2016 to 2020
$1.3M
INTERNATIONAL RESEARCH REGISTRY NETWORK FOR SJOGERNS SYNDROME-268032636N01DE032636 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GREENSPAN, JOHN · 2005 to 2006
–
NEI NIH HHS K23 EY026998NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY026972NHLBI NIH HHS HHSN268201300057CNIDCR NIH HHS N01 DE032636NIDCR NIH HHS U01 DE028891
6 · The paper itself

Abstract

objectiveTo evaluate how ocular, oral, and bodily neuropathic pain symptoms, which characterize small fiber neuropathies, are associated with Sjögren's syndrome (SS) classification based on the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria.

methodsParticipants enrolled in the Sjögren's International Collaborative Clinical Alliance (SICCA) registry had ocular, rheumatologic, oral, and labial salivary gland (LSG) biopsy examinations, blood and saliva samples collected, and completed questionnaires at baseline. We used mixed effects modeling with age, country, gender, and depression being fixed effects and study site, a random effect, to determine if neuropathic pain indicators (assessed via questionnaires) were associated with being classified as SS.

resultsA total of 3,514 participants were enrolled into SICCA, with 1,541 (52.9%) meeting the 2016 ACR/EULAR classification criteria for SS. There was a negative association between being classified as SS and experiencing bodily neuropathic pain features of needle-like pain, prickling/tingling sensation, ocular neuropathic pain of constant burning, and constant light sensitivity, and having a presumptive diagnosis of neuropathic oral pain.

conclusionsWe found that those classified as SS had lower scores/reports of painful neuropathies compared with those classified as non-SS. Non-SS patients with dry eye disease or symptoms could benefit from pain assessment as they may experience painful small-fiber neuropathies (SFNs). Pain questionnaires may help identify pain associated with SFNs in patients with SS and non-SS dry eye. Future studies would be helpful to correlate self-reports of pain to objective measures of SFNs in those with SS, non-SS dry eye, and healthy controls.

Indexed as

Dry Eye SyndromesNeuralgiaSjogren's SyndromeHumansRegistriesSurveys and Questionnairesdry eye diseaseneuropathic painSjögren’s syndrome

Identifiers

PMID33527744
PMCPMC10911963
OpenAlexW3127261196

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.