ArticleArthritis care & research2022
Presence of Magnetic Resonance Imaging-Defined Inflammation Particularly in Overweight and Obese Women Increases Risk of Radiographic Knee Osteoarthritis: The POMA Study.
Article in Arthritis care & research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Deep learning-based effusion-synovitis volume measured on MRI is associated with osteoarthritis progression: A longitudinal analysis of data from the osteoarthritis initiative.Osteoarthritis and cartilage open · 2026Article
- Targeting synovial inflammation in knee osteoarthritis: translational insights for diagnosis and therapy.Journal of orthopaedic translation · 2026Review
- Spatially resolved longitudinal changes in tibial subchondral trabecular bone texture for exploratory prediction of incident knee osteoarthritis.Frontiers in physiology · 2026Article
- Healthy knee asymmetry is a potential risk factor for knee osteoarthritis: Data from the osteoarthritis initiative.Osteoarthritis imaging · 2025Article
- Imaging-based measures of synovitis in knee osteoarthritis: A scoping review and narrative synthesis.Osteoarthritis and cartilage open · 2025Review
- Imaging of osteoarthritis-related bone marrow lesions in clinical trials.Osteoarthritis imaging · 2025Article
- Sexually dimorphic metabolic effects of a high fat diet on knee osteoarthritis in mice.Biology of sex differences · 2024Article
- Bone marrow lesions in osteoarthritis: Characterising genetic and histological changes to understand disease pathophysiology.Osteoarthritis and cartilage open · 2024Review
- Sexual dimorphism in peri-articular tissue anatomy - More keys to understanding sex-differences in osteoarthritis?Osteoarthritis and cartilage open · 2024Review
- Progression of Bone Marrow Lesions and the Development of Knee Osteoarthritis: Osteoarthritis Initiative Data.Radiology · 2024Article
- Survival analysis on subchondral bone length for total knee replacement.Skeletal radiology · 2024Article
- The mediating role of synovitis in meniscus pathology and knee osteoarthritis radiographic progression.Scientific reports · 2024Observational
- Effect of weight loss on knee joint synovitis over 48 months and mediation by subcutaneous fat around the knee: data from the Osteoarthritis Initiative.BMC musculoskeletal disorders · 2024Article
- Update on recent developments in imaging of inflammation in osteoarthritis: a narrative review.Skeletal radiology · 2023Review
- Identification and validation of hub genes and potential drugs involved in osteoarthritis through bioinformatics analysis.Frontiers in genetics · 2023Article
- Effusion-synovitis worsening mediates the association between body mass index and Kellgren-Lawrence progression in obese individuals: data from the Osteoarthritis Initiative.Osteoarthritis and cartilage · 2022Article
- Fundamentals of OA. An initiative of Osteoarthritis and Cartilage. Obesity and metabolic factors in OA.Osteoarthritis and cartilage · 2022Review
- Effects of Greenshell™ mussel intervention on biomarkers of cartilage metabolism, inflammatory markers and joint symptoms in overweight/obese postmenopausal women: A randomized, double-blind, and placebo-controlled trial.Frontiers in medicine · 2022Article
- Deep learning for large scale MRI-based morphological phenotyping of osteoarthritis.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 7 countries.
Funding
Abstract
objectiveThe present study was undertaken to assess whether the odds for incident radiographic osteoarthritis (OA) differ between men and women in regard to body mass index (BMI) and inflammatory magnetic resonance imaging (MRI) markers 1 and 2 years prior, and whether the presence of inflammation on MRI differs between normal-weight and overweight/obese individuals who develop radiographic OA up to 4 years prior.
methodsWe studied 355 knees from the Osteoarthritis Initiative study that developed incident radiographic OA and 355 matched controls. MRIs were read for effusion-synovitis and Hoffa-synovitis for up to 4 consecutive annual time points. Subjects were classified as normal-weight (BMI <25), overweight (BMI ≥25 and <30), or obese (BMI ≥30). Conditional logistic regression was used to assess odds of incident radiographic OA for effusion-synovitis and Hoffa-synovitis at 1 and 2 years prior to radiographic OA incidence (i.e., "P-1" and "P-2") considering BMI category. Bivariate logistic regression was used to assess odds of inflammation for cases only.
resultsOne hundred seventy-eight (25.1%) participants were normal weight, 283 (39.9%) overweight, and 249 (35.1%) obese. At P-2, being overweight with Hoffa-synovitis, which had an odds ratio [OR] of 3.26 (95% confidence interval [95% CI] 1.39-7.65), or effusion-synovitis (OR 3.56 [95% CI 1.45-8.75]) was associated with greater odds of incident radiographic OA in women. For those with incident radiographic OA, there were no increased odds of synovitis in the overweight/obese subgroup for most time points, but increased odds for effusion-synovitis were observed at P-2 (OR 2.21 [95% CI 1.11-4.43]).
conclusionPresence of inflammatory markers seems to play a role especially in overweight women, while obese women have increased odds for radiographic OA also in the absence of these markers.
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