ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021
Generalizability of findings from a clinical sample to a community-based sample: A comparison of ADNI and ARIC.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 47 citations in OpenAlex.
- From Biomarker Anchors to Disease-State Transitions: A Biologically Anchored Probabilistic Principal Component Analysis Framework for Alzheimer's Disease Progression Modeling.Neurology and therapy · 2026Article
- A multimodal model for clinically defined MCI integrating plasma biomarkers and brain microstructural features: a dual-cohort external validation study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- The associations between ATN biomarkers and episodic memory diminish as age increases.European geriatric medicine · 2026Article
- A Multimodal Latent Severity Axis for Alzheimer's Disease: Probabilistic PCA, Bayesian Trajectories, and Stage-Aware Timing Effects.Neurology and therapy · 2026Article
- Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study.Annals of clinical and translational neurology · 2026Article
- Leveraging electronic health records to examine differential clinical outcomes in people with Alzheimer's disease.Communications medicine · 2026Article
- Response to "Brain Amyloid and Cognitive Decline in Late-Life Depression".The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Clinical trials for neuropsychiatric syndromes in major and mild neurocognitive disorders: A CONSORT-based approach.International psychogeriatrics · 2025Review
- Measurement Error and Methodologic Issues in Analyses of the Proportion of Variance Explained in Cognition.Neuropsychology review · 2025Review
- Diagnostic and prognostic multimodal prediction models in Alzheimer's disease: A scoping review.Journal of Alzheimer's disease : JAD · 2025Article
- Ambient Air Pollution and the Severity of Alzheimer Disease Neuropathology.JAMA neurology · 2025Article
- The role of genomic-informed risk assessments in predicting dementia outcomes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Transfer learning reveals the mediating mechanisms of cross-ethnic lipid metabolic pathways in the association between APOE gene and Alzheimer's disease.Briefings in bioinformatics · 2025Article
- Concordance Between Amyloid-PET Quantification and Real-World Visual Reads.JAMA neurology · 2025Article
- The Role of Genomic-Informed Risk Assessments in Predicting Dementia Outcomes.medRxiv : the preprint server for health sciences · 2025Article
- Pathways to Racial/Ethnic Inequalities in Dementia.Annual review of clinical psychology · 2025Review
- Impact of white matter hyperintensities on structural connectivity and cognition in cognitively intact ADNI participants.Neurobiology of aging · 2024Article
- A Comparison of an Australian Observational Longitudinal Alzheimer's Disease Cohort to Community-Based Australian Data.Journal of Alzheimer's disease : JAD · 2024Observational
- The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Racial, Ethnic, and Geographic Diversity in Population Neuroscience.Current topics in behavioral neurosciences · 2024Review
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 1 country.
Funding
Abstract
introductionClinic-based study samples, including the Alzheimer's Disease Neuroimaging Initiative (ADNI), offer rich data, but findings may not generalize to community-based settings. We compared associations in ADNI to those in the Atherosclerosis Risk in Communities (ARIC) study to assess generalizability across the two settings.
methodsWe estimated cohort-specific associations among risk factors, cognitive test scores, and neuroimaging outcomes to identify and quantify the extent of significant and substantively meaningful differences in associations between cohorts. We explored whether using more homogenous samples improved comparability in effect estimates.
resultsThe proportion of associations that differed significantly between cohorts ranged from 27% to 34% across sample subsets. Many differences were substantively meaningful (e.g., odds ratios [OR] for apolipoprotein E ε4 on amyloid positivity in ARIC: OR = 2.8, in ADNI: OR = 8.6). DISCUSSION: A higher proportion of associations differed significantly and substantively than would be expected by chance. Findings in clinical samples should be confirmed in more representative samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.