ArticleJournal of veterinary internal medicine2021
The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia.
Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 2026 iCatCare consensus guidelines on the diagnosis and management of chronic kidney disease in cats.Journal of feline medicine and surgery · 2026Guideline
- Calciprotein particles in cats with naturally occurring chronic kidney disease.Journal of veterinary internal medicine · 2026Article
- Effect of dietary Ca:P ratio on ionized calcium and calcium homeostasis in cats with early-stage chronic kidney disease.PloS one · 2026Article
- Association between lactulose administration and hypercalcemia in dogs medically managed for hepatic encephalopathy.The Canadian veterinary journal = La revue veterinaire canadienne · 2024Article
- Dietary phosphorus and renal disease in cats: where are we?Journal of feline medicine and surgery · 2024Review
- Blood fibroblast growth factor 23 concentration in cats with and without chronic kidney disease: a scoping review.Journal of feline medicine and surgery · 2024Article
- Ionized hypercalcemia can resolve with nutritional modification in cats with idiopathic hypercalcemia or chronic kidney disease.Journal of feline medicine and surgery · 2024Article
- Ionized hypercalcemia in 238 cats from a referral hospital population (2009-2019).Journal of veterinary internal medicine · 2023Article
- Association between serum fibroblast growth factor-23 concentrations and blood calcium levels in chronic kidney disease cats with upper urolithiasis.Journal of feline medicine and surgery · 2022Article
- Alendronate treatment in cats with persistent ionized hypercalcemia: A retrospective cohort study of 20 cases.Journal of veterinary internal medicine · 2022Article
- Drp1 activates ROS/HIF-1α/EZH2 and triggers mitochondrial fragmentation to deteriorate hypercalcemia-associated neuronal injury in mouse model of chronic kidney disease.Journal of neuroinflammation · 2022Article
- Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018).Journal of veterinary internal medicine · 2022Article
- Clinical progression of cats with early-stage chronic kidney disease fed diets with varying protein and phosphorus contents and calcium to phosphorus ratios.Journal of veterinary internal medicine · 2021Article
- The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia.Journal of veterinary internal medicine · 2021Article
- Dietary magnesium supplementation in cats with chronic kidney disease: A prospective double-blind randomized controlled trial.Journal of veterinary internal medicineArticle
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Authors and funding
6 authors.
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Abstract
backgroundHypercalcemia is commonly observed in cats with azotemic chronic kidney disease (CKD). Dietary phosphate restriction is considered standard of care but may contribute to the development of hypercalcemia. The optimal dietary management strategy for these cats is unclear.
objectivesTo describe the effect of feeding a moderately phosphate-restricted diet (MP; 1.5 g/Mcal phosphorus; Ca : P ratio, 1.3) to cats with concurrent azotemic CKD and ionized hypercalcemia. ANIMALS: Client-owned cats with ionized hypercalcemia (ionized calcium [iCa] concentration >1.4 mmol/L) at diagnosis of CKD (n = 11; baseline hypercalcemics) or after CKD diagnosis while eating a phosphate-restricted clinical renal diet (0.8 g/Mcal phosphorus; Ca : P ratio, 1.9; n = 10; RD hypercalcemics).
methodsChanges in variables over time, after starting MP at visit 1, were assessed using linear mixed model analysis within each group of cats. Data are reporte as median [25th, 75th percentiles].
resultsAt visit 1, iCa was 1.47 [1.42, 1.55] mmol/L for baseline hypercalcemics and 1.53 [1.5, 1.67] mmol/L for RD hypercalcemics. Blood iCa decreased (P < .001) when RD hypercalcemics were fed MP, with iCa <1.4 mmol/L in 8/10 cats after 2.2 [1.8, 3.7] months. Plasma phosphate concentrations did not change. In contrast, the baseline hypercalcemic group overall showed no change in iCa but a decrease in plasma phosphate concentration during 8.8 [5.5, 10.6] months on the MP diet, although 4/11 individual cats achieved iCa <1.4 mmol/L by 3.4 [1.0, 6.2] months. CONCLUSIONS AND CLINICAL IMPORTANCE: Attenuation of dietary phosphate restriction could result in normalization of iCa in cats that develop hypercalcemia while eating a clinical renal diet.
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