Evidence map›Paper›PMID 33527508›Full record

ArticleJournal of veterinary internal medicine2021

Hypercoagulability in dogs with chronic enteropathy and association with serum albumin concentration.

Amy Dixon, Edward J Hall, Sophie Adamantos, Aarti Kathrani, Ciara McGrath, Vicki Black

Open access · goldAbstract read
In one paragraph

Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Coagulation status of immune-mediated polyarthritis in dogs.The Journal of small animal practice · 2025
    Article
  4. Article
  5. Article
  6. Comparison of assessment of coagulation in healthy dogs by the TEG 6s and TEG 5000 viscoelastic analyzers.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Amy DixonBristol Veterinary School, University of Bristol, Langford House, Langford, BS40 5DU, United Kingdom.ORCID https://orcid.org/0000-0002-8582-4062
Edward J HallSmall Animal Referral Hospital, Langford Vets, Langford House, Langford, BS40 5DU, United Kingdom.ORCID https://orcid.org/0000-0002-5306-082X
Sophie AdamantosParagon Veterinary Referrals, Paragon Business Village, Red Hall Crescent, Wakefield, West Yorkshire, WF1 2DF, United Kingdom.ORCID https://orcid.org/0000-0002-9494-7793
Aarti KathraniDepartment of Clinical Science and Services, Royal Veterinary College, Hawkshead Lane, Hatfield, Hertfordshire, AL9 7TA, United Kingdom.ORCID https://orcid.org/0000-0001-5569-794X
Ciara McGrathBristol Veterinary School, University of Bristol, Langford House, Langford, BS40 5DU, United Kingdom.
Vicki BlackSmall Animal Referral Hospital, Langford Vets, Langford House, Langford, BS40 5DU, United Kingdom.ORCID https://orcid.org/0000-0002-8486-8127
At Bristol · GBLangdon Hospital · GBParagon 28 (United States) · USRoyal Veterinary College · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDogs with protein-losing enteropathy (PLE) are at risk of developing a hypercoagulable state, but the prevalence of hypercoagulability in dogs with chronic enteropathies (CE) and normal serum albumin concentration is unknown. HYPOTHESIS: Dogs with CE are predisposed to a hypercoagulable state as assessed by thromboelastography (TEG) independent of serum albumin concentration.

methodsDogs with chronic gastrointestinal signs from suspected inflammatory CE between 2017 and 2019 were included. Thirty-eight were evaluated; every dog had a CBC, serum biochemistry panel, and abdominal imaging performed. The Canine Inflammatory Bowel Disease Activity Index (CIBDAI) was calculated. Thromboelastography was performed at presentation, and reaction time (R), kinetic time (K), α-angle, maximal amplitude (MA), and global clot strength (G) were recorded. Dogs were considered hypercoagulable if the G value was ≥25% above the reference interval.

resultsSeventeen of 38 (44.7%; 95% confidence interval [CI], 28.6-61.7%) dogs with CE were hypercoagulable. The G value did not differ between the 19 dogs with normal (≥28 g/L) serum albumin concentrations (9.05 kdyn/cm CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with CE and normal serum albumin concentration can be hypercoagulable as measured by TEG.

Indexed as

Dog DiseasesInflammatory Bowel DiseasesProtein-Losing EnteropathiesThrombophiliaAnimalsDogsSerum AlbuminThrombelastographySerum Albumincaninegastrointestinal thromboembolisminflammationthromboelastography

Identifiers

PMID33527508
PMCPMC7995358
OpenAlexW3126199779

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.