Evidence map›Paper›PMID 33527483›Full record

ReviewLasers in surgery and medicine2021

Reflectance Confocal Microscopy, Optical Coherence Tomography, and Multiphoton Microscopy in Inflammatory Skin Disease Diagnosis.

Ella A Csuka, Suzanne C Ward, Chloe Ekelem, David A Csuka, Marco Ardigò, Natasha A Mesinkovska

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Lasers in surgery and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07098000 (The Role of Confocal Microscopy in Estimating Dupilumab Treatment Response for Moderate/Severe Atopic Dermatitis), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07098000 active not recruitingnot on this mapstarted 2024, after this paper: background citation

The Role of Confocal Microscopy in Estimating Dupilumab Treatment Response for Moderate/Severe Atopic Dermatitis

Typeobservational_patient_registrySponsorHospital Italiano de Buenos AiresRan2024 to 2026Enrolled40ConditionsAtopic Dermatitis
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Noninvasive Diagnosis Revealed a Strong Therapeutic Response and Skin Barrier Changes in Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
    Article
  4. Advances in wound care · 2026
    Article
  5. Review
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  7. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ella A CsukaDepartment of Dermatology, University of California, Irvine, Irvine, California, 92697.ORCID 0000-0001-6698-264X
Suzanne C WardDepartment of Dermatology, University of California, Irvine, Irvine, California, 92697.
Chloe EkelemDepartment of Dermatology, University of California, Irvine, Irvine, California, 92697.ORCID 0000-0002-7919-6901
David A CsukaDepartment of Dermatology, University of California, Irvine, Irvine, California, 92697.
Marco ArdigòSan Gallicano Dermatological Institute-IRCCS, Via Chianesi 53, Rome, 00144, Italy.ORCID 0000-0002-5772-4937
Natasha A MesinkovskaDepartment of Dermatology, University of California, Irvine, Irvine, California, 92697.
University of California, Irvine · USSan Gallicano Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesTechnological advances in medicine have brought about many novel skin imaging devices. This review aims to evaluate the scientific evidence supporting the use of noninvasive optical imaging techniques to aid in the diagnosis and prognosis of inflammatory skin diseases. STUDY DESIGN/MATERIALS AND

methodsPubMed and Scopus were searched in September 2020 according to PRISMA guidelines for articles using reflectance confocal microscopy (RCM), optical coherence tomography (OCT), and multiphoton microscopy (MPM) in inflammatory skin diseases, excluding studies monitoring treatment efficacy.

resultsAt the time of the study, there were 66 articles that addressed the utilization of noninvasive imaging in interface, spongiotic, psoriasiform, vesiculobullous, and fibrosing/sclerosing inflammatory skin dermatoses: RCM was utilized in 46, OCT in 16, and MPM in 5 articles. RCM was most investigated in psoriasiform dermatoses, whereas OCT and MPM were both most investigated in spongiotic dermatoses, including atopic dermatitis and allergic contact dermatitis.

conclusionsThere is preliminary evidence to support the diagnostic potential of noninvasive optical imaging techniques in inflammatory skin diseases. Improvements in the devices and further correlation with histology will help broaden their utility. Additional studies are needed to determine the parameters for diagnostic features, disease differentiation, and staging of inflammatory skin conditions. Lasers Surg. Med. © 2021 Wiley Periodicals LLC.

Indexed as

Dermatitis, AtopicSkin DiseasesHumansMicroscopy, ConfocalSkinTomography, Optical Coherenceinflammatory skin diseasenoninvasive imaging

Identifiers

PMID33527483
OpenAlexW3127237414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.