Evidence map›Paper›PMID 33527378›Full record

ArticleJournal of clinical periodontology2021

Association between periodontitis and severity of COVID-19 infection: A case-control study.

Nadya Marouf, Wenji Cai, Khalid N Said, Hanin Daas, Hanan Diab, Venkateswara Rao Chinta, Ali Ait Hssain, Belinda Nicolau, Mariano Sanz, Faleh Tamimi

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical periodontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05311410 (Viral Kinetics of SARS-CoV-2 in Patients in the Intensive Care Unit Undergoing Dental Procedures), which is not on this map. Cited by 180 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 8 pooled it
53.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05311410 naunknown statusnot on this map

Viral Kinetics of SARS-CoV-2 in Patients in the Intensive Care Unit Undergoing Dental Procedures

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2021 to 2025Enrolled60ConditionsSARS-CoV2 Infection, Viral Load, Oral Diseases, Dental TreatmentArmsNon-bloody dental procedures (control group), Bloody dental procedures (study group)
3 · Its place in the literature

Who cites it

180 citing papers in PubMed, 8 syntheses or guidelines pooled it, 375 citations in OpenAlex.

  1. Pooled it
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  6. Oral Manifestations of COVID-19 in Hospitalized Patients: A Systematic Review.International journal of environmental research and public health · 2021
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  11. Observational
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  17. The Impact of Aging Oral Health on Long COVID-19.Journal of dental research · 2025
    Review
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120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Nadya MaroufDepartment of Dentistry, Oral Health Institute, Hamad Medical Corporation, Doha, Qatar.
Wenji CaiFaculty of Dentistry, McGill University, Montreal, QC, Canada.ORCID 0000-0002-5548-1396
Khalid N SaidDepartment of Dentistry, Oral Health Institute, Hamad Medical Corporation, Doha, Qatar.
Hanin DaasCollege of Dental Medicine, QU Health, Qatar University, Doha, Qatar.
Hanan DiabDepartment of Dentistry, Oral Health Institute, Hamad Medical Corporation, Doha, Qatar.
Venkateswara Rao ChintaHamad Medical Corporation, Doha, Qatar.
Ali Ait HssainHamad Medical Corporation, Doha, Qatar.
Belinda NicolauFaculty of Dentistry, McGill University, Montreal, QC, Canada.
Mariano SanzETEP Research Group, Faculty of Odontology, University Complutense of Madrid, Madrid, Spain.ORCID 0000-0002-6293-5755
Faleh TamimiCollege of Dental Medicine, QU Health, Qatar University, Doha, Qatar.
Hamad Medical Corporation · QAMcGill University · CAQatar University · QAUniversidad Complutense de Madrid · ES

Funding

Hamad Medical Corporation Business Intelligence Center
6 · The paper itself

Abstract

aimCOVID-19 is associated with an exacerbated inflammatory response that can result in fatal outcomes. Systemic inflammation is also a main characteristic of periodontitis. Therefore, we investigated the association of periodontitis with COVID-19 complications. MATERIALS AND

methodsA case-control study was performed using the national electronic health records of the State of Qatar between February and July 2020. Cases were defined as patients who suffered COVID-19 complications (death, ICU admissions or assisted ventilation), and controls were COVID-19 patients discharged without major complications. Periodontal conditions were assessed using dental radiographs from the same database. Associations between periodontitis and COVID 19 complications were analysed using logistic regression models adjusted for demographic, medical and behaviour factors.

resultsIn total, 568 patients were included. After adjusting for potential confounders, periodontitis was associated with COVID-19 complication including death (OR = 8.81, 95% CI 1.00-77.7), ICU admission (OR = 3.54, 95% CI 1.39-9.05) and need for assisted ventilation (OR = 4.57, 95% CI 1.19-17.4). Similarly, blood levels of white blood cells, D-dimer and C Reactive Protein were significantly higher in COVID-19 patients with periodontitis.

conclusionPeriodontitis was associated with higher risk of ICU admission, need for assisted ventilation and death of COVID-19 patients, and with increased blood levels of biomarkers linked to worse disease outcomes.

Indexed as

COVID-19PeriodontitisCase-Control StudiesC-Reactive ProteinHumansSARS-CoV-2C-Reactive ProteinCovid-19deathICU admissionsperiodontitisventilation

Identifiers

PMID33527378
PMCPMC8014679
OpenAlexW3126740247

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.