Evidence map›Paper›PMID 33527338›Full record

ArticleIndian journal of pediatrics2021

Centrifugal Therapeutic Plasma Exchange in Pediatric Patients.

Rekha Hans, Karalanglin Tiewsoh, Divjot Singh Lamba, Lesa Dawman, Satya Prakash, Parmatma Prasad Tripathi, Naveen Sankhyan, Ratti Ram Sharma, Neelam Marwaha

Abstract read
PubMed Publisher
In one paragraph

Article in Indian journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Scope, Safety, and Feasibility of Therapeutic Plasma Exchange in Pediatric Intensive Care Unit: A Single-center Experience.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023
    Article
  3. Pediatric Therapeutic Plasma Exchange: Coming of Age?Indian journal of pediatrics · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Rekha HansDepartment of Transfusion Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Karalanglin TiewsohDepartment of Pediatric Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Divjot Singh LambaDepartment of Transfusion Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Lesa DawmanDepartment of Pediatric Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Satya PrakashDepartment of Transfusion Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Parmatma Prasad TripathiDepartment of Transfusion Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Naveen SankhyanDepartment of Pediatric Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Ratti Ram SharmaDepartment of Transfusion Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. rrsdoc@hotmail.com.
Neelam MarwahaDepartment of Transfusion Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the safety of centrifugal therapeutic plasma exchange (TPE) in pediatric patients.

methodsThe authors did a retrospective analysis of all TPE procedures performed in pediatric patients over a period of 19 y (2001-2019). Procedures were done on different apheretic devices, daily or on alternate days depending on the clinical condition of the patient. Adverse events during the procedure were noted and analyzed.

resultsA total of 672 TPE (with mean of 6.77 ± 4.85) procedures were performed for 99 pediatric patients with different indications like hematological (n = 68), renal (n = 12), neurology (n = 18) and hepatology (n = 1). The mean age was 7.00 ± 3.11 y and weight was 20.72 ± 9.17 kg. Adverse events (AEs) were observed during 34 (5%) procedures, most common were allergic reactions to replacement fluid (2.24%) followed by hypotension (1.04%), symptomatic hypocalcemia (1.04%), line occlusion (0.59%), and febrile non hemolytic transfusion reaction (0.41%). A significant correlation of AEs was observed with weight (p = 0.045), total blood volume of the patient (p = 0.04), increasing number of procedures (p = 0.000) and replacement fluid [Fresh frozen plasma (FFP)] (p = 0.04). All AEs were managed as per departmental standard operating procedures (SOPs) completing procedures successfully except one which was abandoned. No mortality was observed during the procedures.

conclusionTPE is a safe therapeutic modality in pediatric patients when performed under expert technical supervision with proper SOPs in place.

Indexed as

Blood Component RemovalPlasma ExchangeChildChild, PreschoolHumansPlasmaPlasmapheresisRetrospective StudiesAdverse eventsChallengesPediatricTherapeutic plasma exchange

Identifiers

PMID33527338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.