ReviewMolecular neurobiology2021
Could α-Klotho Unlock the Key Between Depression and Dementia in the Elderly: from Animal to Human Studies.
Review in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed.
- Serum Klotho Levels and Major Age-Related Ocular Disorders: A Cross-Sectional and Genetic Association Study.Translational vision science & technology · 2026Article
- Degalactosylated whey protein increases α-Klotho concentrations in the plasma and kidney in mice.Frontiers in nutrition · 2026Article
- Age-dependent biphasic alterations and protein-activity decoupling of plasma BACE1 in major depressive disorder.Frontiers in psychiatry · 2026Article
- Serum klotho levels modify the positive relationship of depression and all-cause mortality risk.Scientific reports · 2025Article
- A bibliometric analysis of research on dementia comorbid with depression from 2005 to 2024.Frontiers in neuroscience · 2025Article
- Association of α-klotho concentrations with cardiovascular and all-cause mortality in American adults with depression: a national prospective cohort study.Translational psychiatry · 2024Article
- Association of cognitive impairment with the interaction between chronic kidney disease and depression: findings from NHANES 2011-2014.BMC psychiatry · 2024Article
- Association of serum klotho with cognitive function among individuals with nonalcoholic fatty liver disease.Frontiers in aging neuroscience · 2024Article
- Improving sleep quality is essential for enhancing soluble Klotho levels in hemodialysis patients.International urology and nephrology · 2023Article
- The Importance of α-Klotho in Depression and Cognitive Impairment and Its Connection to Glutamate Neurotransmission-An Up-to-Date Review.International journal of molecular sciences · 2023Review
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
α-Klotho is known for its aging-related functions and is associated with neurodegenerative diseases, accelerated aging, premature morbidity, and mortality. Recent literature suggests that α-Klotho is also involved in the regulation of mental functions, such as cognition and psychosis. While most of studies of α-Klotho are focusing on its anti-aging functions and protective role in dementia, increasing evidence showed many shared symptoms between depression and dementia, while depression has been proposed as the preclinical stage of dementia such as Alzheimer's disease (AD). To see whether and how α-Klotho can be a key biological link between depression and dementia, in this review, we first gathered the evidence on biological distribution and function of α-Klotho in psychiatric functions from animal studies to human clinical investigations with a focus on the regulation of cognition and mood. Then, we discussed and highlighted the potential common underlying mechanisms of α-Klotho between psychiatric diseases and cognitive impairment. Finally, we hypothesized that α-Klotho might serve as a neurobiological link between depression and dementia through the regulation of oxidative stress and inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.