ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2022
The benefit of cardioneuroablation to reduce syncope recurrence in vasovagal syncope patients: a case-control study.
Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Cardioneuroablation for the treatment of reflex syncope and functional bradyarrhythmias: A Scientific Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS) and the Latin American Heart Rhythm Society (LAHRS).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Guideline
- Cardioneuroablation versus cardiac pacemaker in the management of dominant cardioinhibitory vasovagal syncope: a retrospective cohort study.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Older age is not an independent predictor of syncope recurrence following cardioneuroablation for reflex syncope.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Observational
- Cardioneuroablation for the management of neurally mediated syncope, sinus bradycardia, and atrioventricular block.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Review
- Focal pulsed field ablation for guiding and assessing the acute effect of cardioneuroablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Cardioneuroablation for the management of patients with recurrent vasovagal syncope and symptomatic bradyarrhythmias: the CNA-FWRD Registry.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Observational
- Cardioneuroablation for vasovagal syncope: How to move beyond "learning by burning"?Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Permanent pacing versus cardioneuroablation for cardioinhibitory vasovagal syncope.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Quality of life improvement following cardioneuroablation for vasovagal syncope: expected or too early to say?Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics - 2024 update.The Journal of physiology · 2025Review
- Inappropriate Sinus Tachycardia Following Cardioneuroablation for Reflex Syncope: A Case Report and Review of the Literature Illustrating this Underappreciated Adverse Effect.Arrhythmia & electrophysiology review · 2025Article
- Cardioneuroablation for Asystolic Reflex Syncope: How to Identify the Best Candidate and How to Predict Success.Arrhythmia & electrophysiology review · 2025Review
- Catheter Ablation for Vasovagal Syncope: The Therapeutic Potential of Gateway Plexi.Arrhythmia & electrophysiology review · 2025Review
- Cardioneuroablation for vasovagal syncope: insights on patients' selection, centre settings, procedural workflow and endpoints-results from an European Heart Rhythm Association survey.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- Cardioneuroablation for Cardioinhibitory Vasovagal Syncope: Rationale, Approaches, and Its Role in Long-Term Management.Current cardiovascular risk reports · 2024Article
- Safety observation of antiarrhythmic drug use in a patient with sinus bradycardia following atrial fibrillation radiofrequency ablation combined with cardiac neural ablation: a case report.The Pan African medical journal · 2024Article
- Ganglionated Plexus Ablation Procedures to Treat Vasovagal Syncope.International journal of molecular sciences · 2023Review
- Clinical controversy: methodology and indications of cardioneuroablation for reflex syncope.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Ganglionic Plexus Ablation: A Step-by-step Guide for Electrophysiologists and Review of Modalities for Neuromodulation for the Management of Atrial Fibrillation.Arrhythmia & electrophysiology review · 2023Review
- Cardioneuroablation for Treating Vasovagal Syncope: Current Status and Future Directions.Arrhythmia & electrophysiology review · 2023Review
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdequate and effective therapy for resistant vasovagal syncope patients is lacking and the benefit of cardioneuroablation (CNA) in this cohort is still debated. The aim of this study is to assess the long-term effect of CNA versus conservative therapy (CT) in a retrospectively followed cohort.
methodsA total of 2874 patients underwent head-up tilt test (HUT) and 554 (19.2 %) were reported as positive, with VASIS type 2B response or > 3 s asystole in 130 patients. After exclusion of 29 patients under 18 years and over 65 years of age, 101 patients were included final analysis. Fifty-one patients (50.4%) underwent CNA and 50 (49.6%) patients received CT. After propensity score matching, 19 pairs of patients were successfully matched. The recurrence rate of syncope was compared between groups.
resultsDuring a median follow-up of 22 months (IQR, 13-35), syncope was seen in 12 (11.8%) cases. In the 19 propensity-matched patients, recurrent syncope was observed in 8 patients in the CT group and in 2 patients in the CNA group, respectively. In mixed effect Cox regression analysis, CNA was associated with less syncope recurrence risk at follow-up (HR 0.23, 95% CI 0.03-0.99, p = 0.049). The 4-year Kaplan-Meier syncope free rate was 0.86 (95% CI, 0.63-1.00) for CNA group and 0.50 (95% CI, 0.30-0.82) for CT group in the matched cohort.
conclusionsIn highly selected patients with HUT-induced cardioinhibitory response, CNA is associated with a significant reduction in syncope recurrence during follow-up when compared to CT.
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