Evidence map›Paper›PMID 33527184›Full record

ArticleProbiotics and antimicrobial proteins2021

Hyperglycemia-Induced Cardiac Damage Is Alleviated by Heat-Inactivated Lactobacillus reuteri GMNL-263 via Activation of the IGF1R Survival Pathway.

Ker-Ping Koay, Bruce Chi-Kang Tsai, Chia-Hua Kuo, Wei-Wen Kuo, Hsiang-Ning Luk, Cecilia Hsuan Day, Ray-Jade Chen, Michael Yu-Chih Chen, V Vijaya Padma, Chih-Yang Huang

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Life (Basel, Switzerland) · 2026
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  5. Review
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  8. Exercise renovates HBiogerontology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Ker-Ping Koay *Department of Anesthesia, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Bruce Chi-Kang TsaiCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Chia-Hua KuoLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Wei-Wen Kuo *Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.
Hsiang-Ning LukDepartment of Anesthesia, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Cecilia Hsuan DayDepartment of Nursing, MeiHo University, Pingtung, Taiwan.
Ray-Jade ChenDepartment of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Michael Yu-Chih ChenDepartment of Cardiology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
V Vijaya PadmaDepartment of Biotechnology, Bharathiar University, Coimbatore, India.
Chih-Yang HuangCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. cyhuang@mail.cmu.edu.tw.ORCID http://orcid.org/0000-0003-2347-0411
Tzu Chi Foundation · TWAsia University · TWBharathiar University · INChina Medical University · TWMeiho University · TWTaipei Medical University · TWUniversity of Taipei · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes-induced cardiomyocyte apoptosis is one of the major causes of mortality in patients with diabetes. Numerous studies have indicated the beneficial effects of Lactobacillus reuteri GMNL-263. However, the protective effect of Lactobacillus reuteri GMNL-263 in cardiac damage associated with diabetes remains poorly understood. In this study, we aimed to investigate the protective effect of Lactobacillus reuteri GMNL-263 on cardiomyocytes in diabetic rats. Five-week-old male Wistar rats were categorized into normal control group, diabetes group (55 mg/kgw STZ-induced diabetes via intraperitoneal injection), and diabetic animals treated with Lactobacillus reuteri GMNL-263 (10

Indexed as

Cardiotonic AgentsDiabetes Mellitus, ExperimentalHyperglycemiaLimosilactobacillus reuteriMyocytes, CardiacAnimalsHot TemperatureMaleRatsRats, WistarReceptor, IGF Type 1Cardiotonic AgentsIgf1r protein, ratReceptor, IGF Type 1DiabetesGMNL-263HeartHyperglycemiaIGF1R

Identifiers

PMID33527184
OpenAlexW3128552334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.