Evidence map›Paper›PMID 33527122›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021

The Importance of Advancing Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines in Children.

Carol M Kao, Walter A Orenstein, Evan J Anderson

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  14. Strategies and safety considerations of booster vaccination in COVID-19.Bosnian journal of basic medical sciences · 2022
    Review
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  17. Safety & effectiveness of COVID-19 vaccines: A narrative review.The Indian journal of medical research · 2022
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Carol M KaoDepartment of Pediatrics, Emory University School of Medicine, Emory + Children's Pediatric Institute, Atlanta, Georgia, USA.
Walter A OrensteinDepartment of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Evan J AndersonDepartment of Pediatrics, Emory University School of Medicine, Emory + Children's Pediatric Institute, Atlanta, Georgia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the role of children in the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains to be defined, children likely play an important role based on our knowledge of other respiratory viruses. Children are more likely to be asymptomatic or have milder symptoms and less likely to present for healthcare and be tested for SARS-CoV-2. Thus, our current estimates are likely under-representative of the true burden of SARS-CoV-2 in children. Given the potential direct benefit of a SARS-CoV-2 vaccine in children and the substantial indirect benefit through community protection, or "herd immunity," we argue that planning and implementation of SARS-CoV-2 vaccines should include children. Furthermore, community protection occurred after widespread implementation of prior childhood vaccines against Streptococcus pneumoniae, rubella, and rotavirus. We detail considerations for vaccine clinical trials, potential barriers to the implementation of widespread vaccination and argue why children would be an ideal target population for vaccination.

Indexed as

COVID-19Viral VaccinesChildCOVID-19 VaccinesHumansImmunity, HerdSARS-CoV-2COVID-19 VaccinesViral Vaccinescommunity protectionimmunizationpediatricsSARS-CoV-2

Identifiers

PMID33527122
PMCPMC7314192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.