Evidence map›Paper›PMID 33527029›Full record

ArticleAmerican journal of translational research2021

Ozonated autohemotherapy elevates PPAR-γ expression in CD4

Jinrong Zeng, Zhen Tang, Yuezhong Zhang, Xiaoliang Tong, Jianhua Dou, Lihua Gao, Shu Ding, Jianyun Lu

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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  9. Analysis ofInternational journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jinrong ZengDepartment of Dermatology, The Third Xiangya Hospital, Central South University Changsha, Hunan, China.
Zhen TangDepartment of Dermatology, The Third Xiangya Hospital, Central South University Changsha, Hunan, China.
Yuezhong ZhangXiangya School of Medicine, Central South University Changsha, Hunan, China.
Xiaoliang TongDepartment of Dermatology, The Third Xiangya Hospital, Central South University Changsha, Hunan, China.
Jianhua DouDepartment of Dermatology, The Third Xiangya Hospital, Central South University Changsha, Hunan, China.
Lihua GaoDepartment of Dermatology, The Third Xiangya Hospital, Central South University Changsha, Hunan, China.
Shu DingDepartment of Dermatology, The Third Xiangya Hospital, Central South University Changsha, Hunan, China.
Jianyun LuDepartment of Dermatology, The Third Xiangya Hospital, Central South University Changsha, Hunan, China.
Third Xiangya Hospital · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis is widely accepted as a metabolic syndrome with significantly abnormal lipid metabolism and high level of blood lipids that induce a persistent low level of inflammatory condition in patients. T cell mediated immune response plays a critical role in the occurrence and persistence of psoriasis lesions. Hyperlipidemia and associated inflammatory reaction are believed to be the major risk factors for the onset and recurrence of psoriasis. Peroxisome proliferator activated receptor-gamma (PPAR-γ) is known to effectively regulate the blood lipid level and inhibit inflammatory reaction. In this study, we examined the efficacy of ozonated autohemotherapy (OAHT) treatment on psoriatic patients by evaluating the Psoriasis Area and Severity Index (PASI) score and blood lipid level. In addition, PPAR-γ expression level and the correlation of PASI scores or blood lipid level with the PPAR-γ expression were also assessed to determine the psoriasis-associate targets of OAHT. We found that OAHT significantly decreased patients' PASI scores and increased blood HDL-C level. Furthermore, we found that PPAR-γ expression in CD4

Indexed as

CD4+ T cellshyperlipidemiaOzonated autohemotherapyPPAR-γpsoriasis

Identifiers

PMID33527029
PMCPMC7847517
OpenAlexW3128816282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.