Evidence map›Paper›PMID 33526970›Full record

Trial reportInternational journal of medical sciences2021

Regulatory effects of

Wan-Hua Tsai, Chia-Hsuan Chou, Ying-Ju Chiang, Ching-Gong Lin, Che-Hsin Lee

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in International journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Acne and the cutaneous microbiome: A systematic review of mechanisms and implications for treatments.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Pooled it
  2. Pooled it
  3. Trial
  4. Cells · 2023
    Trial
  5. Effects ofNutrients · 2021
    Trial
  6. Review
  7. Review
  8. Article
  9. Cosmetic Interventions for Skin Microbiome Modulation: Current Strategies and Future Directions.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
    Review
  10. Review
  11. Article
  12. Review
  13. Microbiome-Derived Indole-3-Lactic Acid AttenuatesInternational journal of molecular sciences · 2026
    Article
  14. Review
  15. Review
  16. Extracellular vesicles fromFrontiers in immunology · 2026
    Article
  17. Lyophilized Cell-Free Supernatants ofLife (Basel, Switzerland) · 2025
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Wan-Hua TsaiResearch and Development Department, GenMont Biotech Incorporation, Tainan, Taiwan.
Chia-Hsuan ChouResearch and Development Department, GenMont Biotech Incorporation, Tainan, Taiwan.
Ying-Ju ChiangResearch and Development Department, GenMont Biotech Incorporation, Tainan, Taiwan.
Ching-Gong LinBachelor Program in Cosmeceutical and Biotech industry, Department of Cosmetic Science, Chia Nan University of Pharmacy & Science.
Che-Hsin LeeDepartment of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.
GenMont Biotech (Taiwan) · TWChia Nan University of Pharmacy and Science · TWNational Sun Yat-sen University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria response to their environment by producing some compounds which are used in cosmetic and pharmaceutical applications. Some probiotics can regulate immune response and modulate the symptoms of several diseases. Bacteria affect skin response to skin care products. Bacteria are thought to play an important role in acne incidence, skin moisture, and nutrient metabolism, but only a few studies have focused on the extracts of

Indexed as

AdultAnimalsBiofilmsCell Line, TumorCollagenFemaleFibroblastsHumansLactiplantibacillus plantarumMaleMiceMicrobiotaMiddle AgedOintmentsProbioticsPropionibacteriaceaeCollagenOintmentscare productsLactobacillus plantarum-GMNL6probioticsskin care

Identifiers

PMID33526970
PMCPMC7847631
OpenAlexW3119648441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.