ArticleNature genetics2021
Metabolic control of DNA methylation in naive pluripotent cells.
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Article in Nature genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
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Who cites it
35 citing papers in PubMed, 57 citations in OpenAlex.
- Antisense Oligonucleotide-MediatedAnimals : an open access journal from MDPI · 2026Article
- Mechanisms coordinating exit from the stem cell state in mammals.Genes & development · 2026Review
- TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency.Cell stem cell · 2026Article
- Serum coating enables feeder-free culture of naive human pluripotent stem cells preserving developmental potential.The EMBO journal · 2026Article
- Integrated multi-omics analysis reveals comprehensive metabolism-driven tumor heterogeneity and immune microenvironment in hepatocellular carcinomas.Scientific reports · 2026Article
- Metabolic control of feto-placental development and pregnancy outcomes.Nature reviews. Endocrinology · 2026Review
- SOCS3 deficiency drives the primed to naive pluripotency transition by sustaining STAT3 activation.Frontiers in genetics · 2026Article
- BACH1 recruits STAT3 to enhance leukemia inhibitory factor receptor activity and augments the self-renewal capacity of mouse embryonic stem cells.Stem cell research & therapy · 2025Article
- DNA methylation and transcription factor-driven immune subtypes in ovarian cancer.Discover oncology · 2025Article
- Review
- STAT3 signaling enhances tissue expansion during postimplantation mouse development.Cell reports · 2025Article
- Predicting differentially methylated cytosines in TET and DNMT3 knockout mutants via a large language model.Briefings in bioinformatics · 2025Article
- Pluripotency genes of mammals: a network at work.Frontiers in bioengineering and biotechnology · 2025Review
- STAT3-dependent long non-coding RNA Lncenc1 contributes to mouse ES cells pluripotency via stabilizing Klf4 mRNA.Briefings in functional genomics · 2024Article
- Predicting Differentially Methylated Cytosines in TET and DNMT3 Knockout Mutants via a Large Language Model.bioRxiv : the preprint server for biology · 2024Article
- Downregulating DNA methyltransferase 3B by suppressing the PI3K/Akt signaling pathway enhances the chemosensitivity of glioblastoma to temozolomide.Molecular neurobiology · 2024Article
- Metaboepigenetic regulation of gene expression in obesity and insulin resistance.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- SRRM2 splicing factor modulates cell fate in early development.Biology open · 2024Article
- Glucose-derived glutamate drives neuronal terminal differentiation in vitro.EMBO reports · 2024Article
- DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation.Nature structural & molecular biology · 2024Article
Corrections and comments
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Authors and funding
21 authors at 8 institutions in 5 countries.
Riccardo M BettoDepartment of Molecular Medicine, Medical School, University of Padua, Padua, Italy.ORCID http://orcid.org/0000-0001-5083-0668
Linda DiamanteDepartment of Molecular Medicine, Medical School, University of Padua, Padua, Italy.ORCID http://orcid.org/0000-0002-3268-1707
Valentina PerreraDepartment of Molecular Medicine, Medical School, University of Padua, Padua, Italy.
Matteo AudanoDepartment of Pharmacological and Biomolecular Sciences (DiSFeB), University of Milan, Milan, Italy.
Stefania RapelliDepartment of Life Sciences and Systems Biology, University of Turin, Turin, Italy.
Andrea LauriaDepartment of Life Sciences and Systems Biology, University of Turin, Turin, Italy.
Danny IncarnatoDepartment of Life Sciences and Systems Biology, University of Turin, Turin, Italy.
Mattia ArboitDepartment of Molecular Medicine, Medical School, University of Padua, Padua, Italy.
Silvia PedrettiDepartment of Pharmacological and Biomolecular Sciences (DiSFeB), University of Milan, Milan, Italy.
Giovanni RigoniDepartment of Biology, University of Padua, Padua, Italy.
Vincent GuerineauUniversité Paris-Saclay, Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France.
David TouboulUniversité Paris-Saclay, Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France.
Giuliano Giuseppe StirparoWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5911-8682
Tim LohoffWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9333-842X
Thorsten BoroviakDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-8703-8949
Paolo GrumatiTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.
Maria E SorianoDepartment of Biology, University of Padua, Padua, Italy.
Jennifer NicholsWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-8650-1388
Nico MitroDepartment of Pharmacological and Biomolecular Sciences (DiSFeB), University of Milan, Milan, Italy. nico.mitro@unimi.it.ORCID http://orcid.org/0000-0002-5000-3619
Salvatore OlivieroDepartment of Life Sciences and Systems Biology, University of Turin, Turin, Italy. salvatore.oliviero@unito.it.ORCID http://orcid.org/0000-0002-3405-765X
Graziano MartelloDepartment of Molecular Medicine, Medical School, University of Padua, Padua, Italy. graziano.martello@unipd.it.ORCID http://orcid.org/0000-0001-5520-085X
University of Padua · ITWellcome/MRC Cambridge Stem Cell Institute · GBItalian institute for Genomic Medicine · ITUniversity of Milan · ITCentre National de la Recherche Scientifique · FRScuola Internazionale Superiore di Studi Avanzati · ITTelethon Institute Of Genetics And Medicine · ITUniversity of Groningen · NL
Funding
Biotechnology and Biological Sciences Research Council RG77233Medical Research Council MC_PC_17230
Abstract
Naive epiblast and embryonic stem cells (ESCs) give rise to all cells of adults. Such developmental plasticity is associated with genome hypomethylation. Here, we show that LIF-Stat3 signaling induces genomic hypomethylation via metabolic reconfiguration. Stat3
Indexed as
AnimalsBlastocystCell DifferentiationCells, CulturedDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3ADNA Methyltransferase 3BEmbryonic Stem CellsGene Expression RegulationHistonesKetoglutaric AcidsLeukemia Inhibitory FactorMiceMice, KnockoutNerve Tissue ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Methyltransferase 3BDnmt3a protein, mousehistone H3 trimethyl Lys4HistonesKetoglutaric AcidsLeukemia Inhibitory FactorLif protein, mouseNerve Tissue ProteinsOtx3 protein, mouseOtx Transcription FactorsStat3 protein, mouseSTAT3 Transcription Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.