SynthesisPediatric research2021
Neonatal jaundice and autism spectrum disorder: a systematic review and meta-analysis.
Synthesis in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Burden and risk factors of autism spectrum disorder: global study and analysis.Pediatric research · 2026Article
- The Association Between Neonatal Jaundice and Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder: Findings From the Millennium Cohort Study.Journal of autism and developmental disorders · 2026Article
- The Association Between Clinically Diagnosed Neonatal Jaundice and Autism: A Swedish Register-Based Cohort Study.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Factors Affecting the Relationship Between Total and Unbound Bilirubin in Preterm and Term Infants.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- A Low-Field MRI Dataset For Spatiotemporal Analysis of Developing Brain.Scientific data · 2025Article
- Analysis of Obstetric Nursing Interventions for Home Monitoring of Neonatal Jaundice.Journal of multidisciplinary healthcare · 2025Article
- Socio-medical factors associated with neurodevelopmental disorders on the Kenyan coast.PLOS global public health · 2025Article
- Neonatal phototherapy and risk of epilepsy-A Danish population based study.European journal of pediatrics · 2024Article
- Neonatal risk factors associated with autism spectrum disorders: an umbrella review.Clinical and experimental pediatrics · 2024Article
- [Advances in Mendelian randomization studies on autism spectrum disorder].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- [Preventive early intervention strategies for neurodevelopmental disorders of high-risk infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Causal relationships of neonatal jaundice, direct bilirubin and indirect bilirubin with autism spectrum disorder: A two-sample Mendelian randomization analysis.Frontiers in public health · 2023Article
- The relationship between gut microbiota and neonatal pathologic jaundice: A pilot case-control study.Frontiers in microbiology · 2023Article
- Risk factors for neonatal hyperbilirubinemia: a systematic review and meta-analysis.Translational pediatrics · 2022Article
- Review
- Risk of autism spectrum disorder in children with a history of hospitalization for neonatal jaundice.Turkish journal of medical sciences · 2021Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTwo meta-analyses concluded that jaundice was associated with an increased risk of autism. We hypothesize that these findings were due to methodological limitations of the studies included. Neonatal jaundice affects many infants and risks of later morbidity may prompt physicians towards more aggressive treatment.
methodsTo conduct a systematic literature review and a meta-analysis of the association between neonatal jaundice and autism with particular attention given to low risk of bias studies. Pubmed, Scopus, Embase, Cochrane, and Google Scholar were searched for publications until February 2019. Data was extracted by use of pre-piloted structured sheets. Low risk of bias studies were identified through predefined criteria.
resultsA total of 32 studies met the inclusion criteria. The meta-analysis of six low risk of bias studies showed no association between neonatal jaundice and autism; cohort studies risk ratio 1.09, 95% CI, 0.99-1.20, case-control studies odds ratio 1.29 95% CI 0.95, 1.76. Funnel plot of all studies suggested a high risk of publication bias.
conclusionsWe found a high risk of publication bias, selection bias, and potential confounding in all studies. Based on the low risk of bias studies there was no convincing evidence to support an association between neonatal jaundice and autism. IMPACT: Meta-analysis of data from six low risk of bias studies indicated no association between neonatal jaundice and autism spectrum disorder. Previous studies show inconsistent results, which may be explained by unadjusted confounding and selection bias. Funnel plot suggested high risk of publication bias when including all studies. There is no evidence to suggest jaundice should be treated more aggressively to prevent autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.