ArticleJournal of cell science2021
Adenine nucleotide translocase regulates airway epithelial metabolism, surface hydration and ciliary function.
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Article in Journal of cell science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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0cells of the map it votes in
23citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
What it found
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Computational modeling of substrate-dependent lung mitochondrial respiration and bioenergetics in rats with different susceptibility to hyperoxia-induced ARDS.American journal of physiology. Cell physiology · 2026Article
- Adenine nucleotide translocase 2 (ANT2) deficiency reprograms ferroptosis in alveolar progenitor cells to promote emphysema.bioRxiv : the preprint server for biology · 2026Article
- Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease.Physiological reviews · 2026Review
- Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026Review
- Review
- NAMs for closing knowledge gaps in assessment of respiratory uptake - a PARC project.Frontiers in toxicology · 2026Article
- ANT1 Deficiency Impairs Macrophage Metabolism and Migration, Protecting Against Emphysema in Chronic Obstructive Pulmonary Disease.American journal of respiratory cell and molecular biology · 2025Article
- Mechanisms and markers of lung ageing in health and disease.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Airway-derived emphysema-specific alveolar type II cells exhibit impaired regenerative potential in COPD.The European respiratory journal · 2024Article
- Interpretable machine learning uncovers epithelial transcriptional rewiring and a role for Gelsolin in COPD.JCI insight · 2024Article
- Microphysiological Models of Lung Epithelium-Alveolar Macrophage Co-Cultures to Study Chronic Lung Disease.Advanced biology · 2024Article
- Amoebae: beyond pathogens- exploring their benefits and future potential.Frontiers in cellular and infection microbiology · 2024Review
- Dysfunctional Epithelial Barrier Is Characterized by Reduced E-Cadherin in Idiopathic Subglottic Stenosis.The Laryngoscope · 2024Article
- Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2023Article
- Adenine nucleotide carrier protein dysfunction in human disease.IUBMB life · 2023Review
- Cigarette smoke-induced injury induces distinct sex-specific transcriptional signatures in mice tracheal epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Article
- Spatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface.Communications biology · 2023Article
- Loss of E-cadherin is causal to pathologic changes in chronic lung disease.Communications biology · 2022Article
- Epithelial plasticity in COPD results in cellular unjamming due to an increase in polymerized actin.Journal of cell science · 2022Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Corrine R KlimentDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ckliment@pitt.edu dnr@jhmi.edu.ORCID 0000-0002-3815-9370
Jennifer M K NguyenDepartment of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Mary Jane KaltreiderDepartment of Medicine, Division of Pulmonary and Critical Care, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0003-2868-2050
YaWen LuDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-0479-1471
Steven M ClaypoolDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Josiah E RadderDepartment of Medicine, Division of Pulmonary and Critical Care, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Frank C SciurbaDepartment of Medicine, Division of Pulmonary and Critical Care, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Yingze ZhangDepartment of Medicine, Division of Pulmonary and Critical Care, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Alyssa D GregoryDepartment of Medicine, Division of Pulmonary and Critical Care, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Pablo A IglesiasDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Venkataramana K SidhayeDepartment of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-4506-8549
Douglas N RobinsonDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ckliment@pitt.edu dnr@jhmi.edu.ORCID 0000-0003-1236-4891
Johns Hopkins University · USUniversity of Pittsburgh · US
Funding
BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1MTranslational StudiesP30DK072506 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRIZZELL, RAYMOND A · 2005 to 2017
$12.5MThe Biochemical Basis for the Mechanics of CytokinesisR01GM066817 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROBINSON, DOUGLAS N · 2003 to 2025
$7.3MRole of E-cadherin in modulating airway epithelial function and parenchymal remodelingR01HL151107 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIDHAYE, VENKATARAMANA K · 2020 to 2023
$2.4MActin-myosin contractility promotes the development of chronic bronchitisR01HL124099 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIDHAYE, VENKATARAMANA K · 2017 to 2021
$2.1MCardiolipin and the mitochondrial ADP/ATP carrier interactomeR01HL108882 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CLAYPOOL, STEVEN MICHAEL · 2013 to 2017
$2.0MThe Role of Adenine Nucleotide Translocase in the Protection of Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease (COPD)K08HL141595 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLIMENT, CORRINE R · 2018 to 2022
$813kZeiss LSM780 Confocal Microscope for a Core FacilityS10OD016374 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2013 to 2013
$584kMitochondrial Genes as New Targets in the Protection of Airway Epithelial Cells Against Cigarette SmokeF32HL129660 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KLIMENT, CORRINE R · 2016 to 2016
$53kNHLBI NIH HHS F32 HL129660NHLBI NIH HHS K08 HL141595NHLBI NIH HHS R01 HL108882NHLBI NIH HHS R01 HL124099NHLBI NIH HHS R01 HL151107NIDDK NIH HHS P30 DK072506NIGMS NIH HHS R01 GM066817NIGMS NIH HHS T32 GM007445NIH HHS S10 OD016374
Abstract
Airway hydration and ciliary function are critical to airway homeostasis and dysregulated in chronic obstructive pulmonary disease (COPD), which is impacted by cigarette smoking and has no therapeutic options. We utilized a high-copy cDNA library genetic selection approach in the amoeba
Indexed as
DictyosteliumPulmonary Disease, Chronic ObstructiveEpithelial CellsHumansLungMitochondriaMitochondrial ADP, ATP TranslocasesMitochondrial ADP, ATP TranslocasesAdenine nucleotide translocaseAirway epitheliumCigarette smokeMitochondriaSLC25A4SLC25A5
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.