Evidence map›Paper›PMID 33526699›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Cytoplasmic synthesis of endogenous

Shinichi Fukuda, Akhil Varshney, Benjamin J Fowler, Shao-Bin Wang, Siddharth Narendran, Kameshwari Ambati, Tetsuhiro Yasuma, Joseph Magagnoli, Hannah Leung, Shuichiro Hirahara and 49 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Trial
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    Review
  11. Association of nucleoside reverse transcriptase inhibitor use with reduced risk of Alzheimer's disease risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

59 authors at 18 institutions in 7 countries.

Shinichi FukudaCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.
Akhil VarshneyCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0003-0759-0982
Benjamin J FowlerDepartment of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY 40536.
Shao-Bin WangCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0002-6699-9406
Siddharth NarendranCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0002-9220-8049
Kameshwari AmbatiCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.
Tetsuhiro YasumaDepartment of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY 40536.ORCID 0000-0003-3731-6546
Joseph MagagnoliDorn Research Institute, Columbia Veterans Affairs Health Care System, Columbia, SC 29209.
Hannah LeungCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.
Shuichiro HiraharaCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.
Yosuke NagasakaCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.
Reo YasumaCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0001-6205-1151
Ivana ApicellaCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0002-2716-5003
Felipe PereiraCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0001-8884-2816
Ryan D MakinCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0002-8804-4125
Eamonn MagnerDepartment of Computer Science, University of Kentucky, Lexington, KY 40536.
Xinan LiuDepartment of Computer Science, University of Kentucky, Lexington, KY 40536.
Jian SunCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0002-5129-9693
Mo WangDoheny Eye Institute, Los Angeles, CA 90033.
Kirstie BakerDoheny Eye Institute, Los Angeles, CA 90033.
Kenneth M MarionDoheny Eye Institute, Los Angeles, CA 90033.
Xiwen HuangDepartment of Computer Science, University of Kentucky, Lexington, KY 40536.
Elmira BaghdasaryanDoheny Eye Institute, Los Angeles, CA 90033.
Meenakshi AmbatiCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.
Vidya L AmbatiCenter for Digital Image Evaluation, Charlottesville, VA 22901.
Akshat PandeyCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.
Lekha PandyaCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.
Tammy CummingsDorn Research Institute, Columbia Veterans Affairs Health Care System, Columbia, SC 29209.
Daipayan BanerjeeCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.
Peirong HuangCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0003-2793-1473
Praveen YerramothuCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0001-6635-6681
Genrich V TolstonogDepartment of Otolaryngology-Head and Neck Surgery, University Hospital of Lausanne, 1011 Lausanne, Switzerland.
Ulrike HeldDepartment of Medical Biotechnology, Paul Ehrlich Institute, 63225 Langen, Germany.
Jennifer A ErwinThe Lieber Institute for Brain Development, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0002-6784-9290
Apua C M PaquolaThe Lieber Institute for Brain Development, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Joseph R HerdyLaboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037.ORCID 0000-0002-8636-8134
Yuichiro OguraDepartment of Ophthalmology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
Hiroko TerasakiDepartment of Ophthalmology, Graduate School of Medicine, Nagoya University, Nagoya 464-8601, Japan.
Tetsuro OshikaDepartment of Ophthalmology, University of Tsukuba, Ibaraki 305-8575, Japan.ORCID 0000-0002-9071-7018
Shaban DarwishCenter for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618.ORCID 0000-0001-6228-4529
Ramendra K SinghCenter for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618.ORCID 0000-0003-3196-6548
Saghar MozaffariCenter for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618.
Deepak BhattaraiDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536.
Kyung Bo KimDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536.ORCID 0000-0003-4744-2466
James W HardinDorn Research Institute, Columbia Veterans Affairs Health Care System, Columbia, SC 29209.ORCID 0000-0003-0506-5500
Charles L BennettDorn Research Institute, Columbia Veterans Affairs Health Care System, Columbia, SC 29209.ORCID 0000-0002-8645-5705
David R HintonDepartment of Ophthalmology, University of Southern California Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Timothy E HansonMedtronic, Inc., Minneapolis, MN 55432.
Christian RöverDepartment of Medical Statistics, University Medical Center Göttingen, D-37073 Göttingen, Germany.ORCID 0000-0002-6911-698X
Keykavous ParangCenter for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618.ORCID 0000-0001-8600-0893
Nagaraj KerurCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.
Jinze LiuDepartment of Computer Science, University of Kentucky, Lexington, KY 40536.
Brian C WernerDepartment of Orthopaedic Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908.
S Scott SuttonDorn Research Institute, Columbia Veterans Affairs Health Care System, Columbia, SC 29209.ORCID 0000-0002-3889-6178
Srinivas R SaddaDoheny Eye Institute, Los Angeles, CA 90033.
Gerald G SchumannDepartment of Medical Biotechnology, Paul Ehrlich Institute, 63225 Langen, Germany.ORCID 0000-0003-1400-3424
Bradley D GelfandCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0003-4619-9409
Fred H GageLaboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037; gage@salk.edu ja9qr@virginia.edu.ORCID 0000-0002-0938-4106
Jayakrishna AmbatiCenter for Advanced Vision Science, School of Medicine, University of Virginia, Charlottesville, VA 22908; gage@salk.edu ja9qr@virginia.edu.ORCID 0000-0003-1622-6365
University of Virginia · USUniversity of Kentucky · USUniversity of South Carolina · USTarget (United States) · USDoheny Eye Institute · USCenter for Digital Image Evaluation · USJohns Hopkins University · USNagoya City University · JPPaul Ehrlich Institut · DESalk Institute for Biological Studies · USUniversity of California, Los Angeles · USUniversity of Tsukuba · JPAravind Eye Hospital · INNagoya University · JPUniversitätsmedizin Göttingen · DEUniversity Hospital of Lausanne · CHUniversity of Minnesota · USUniversity of Southern California · US

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Alan Saghatelian · 1985 to 2026
$82.8M
Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
EXPERIMENTAL APPROACH TO MACULOPATHYR01EY001545 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HINTON, DAVID R. · 1985 to 2016
$6.0M
Form and function of our Janus faced genomeDP1GM114862 · NIGMS · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA · 2014 to 2018
$4.0M
KENTUCKY CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCEUL1RR033173 · NCRR · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2011 to 2011
$3.5M
Functional studies of DICER1 and Alu RNA in geographic atrophyR01EY022238 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA · 2012 to 2016
$3.3M
Visual system and cognitive biology in normal animals versus in an animal model of Alzheimer's disease with or without diabetes treated with solo or dual inflammasome inhibitorsR01EY031039 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA, GELFAND, BRADLEY DAVID · 2020 to 2024
$3.2M
Non-canonical inflammasome in activation in RPE degenerationR01EY029799 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA · 2019 to 2022
$2.7M
Inflammasome Activation in Geographic AtrophyR01EY024068 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA · 2014 to 2017
$2.6M
Clinical Scholars In Cardiovascular ScienceT32HL091812 · NHLBI · UNIVERSITY OF KENTUCKY · PI SMYTH, SUSAN S. · 2008 to 2018
$2.3M
Antigen-independent suppression of ocular angiogenesis via the Fc receptorR01EY028027 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA, GELFAND, BRADLEY DAVID · 2018 to 2022
$2.2M
Non-canonical NLRP3 Inflammasome Activation in Geographic AtrophyR00EY024336 · NEI · UNIVERSITY OF VIRGINIA · PI KERUR, NAGARAJ · 2016 to 2018
$747k
NCATS NIH HHS UL1 TR000117NCI NIH HHS P30 CA014195NCRR NIH HHS UL1 RR033173NEI NIH HHS K99 EY024336NEI NIH HHS R00 EY024336NEI NIH HHS R01 EY001545NEI NIH HHS R01 EY022238NEI NIH HHS R01 EY024068NEI NIH HHS R01 EY028027NEI NIH HHS R01 EY029799NEI NIH HHS R01 EY031039NEI NIH HHS R21 EY030651NHLBI NIH HHS T32 HL091812NIGMS NIH HHS DP1 GM114862
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alu ElementsAnimalsCytoplasmDNA, ComplementaryEpitheliumHumansLong Interspersed Nucleotide ElementsMacular DegenerationRetinal PigmentsRetroelementsReverse TranscriptionDNA, ComplementaryRetinal PigmentsRetroelementsAluhealth insurance databasesmacular degenerationretinaretrotransposon

Identifiers

PMID33526699
PMCPMC8017980
OpenAlexW3128986733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.