ArticleProceedings of the National Academy of Sciences of the United States of America2021
Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
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Who cites it
35 citing papers in PubMed, 44 citations in OpenAlex.
- Gut-Heart Axis in HFpEF: The Emerging Role of Microbiome-Driven Inflammation and Endothelial Dysfunction.Biomolecules · 2026Review
- Bile acid signaling, metabolism, and aging.Liver research (Beijing, China) · 2026Review
- Global Trends in Research of Intestinal Cells and Type 2 Diabetes Mellitus: A Bibliometric and Visualized Analysis from 2004 to 2023.Endocrine, metabolic & immune disorders drug targets · 2026Review
- Microbial changes resulting from VSG attenuate MASLD by modulating bile acid metabolism and the intestinal FXR-FGF19 axis.mSystems · 2025Article
- Unraveling the enterohepatic paradigm in sleeve gastrectomy: bile acids lead, microbiome follows.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Differential roles of individual bile acid in physiology and disease.Pharmacological research · 2025Review
- Multi-omics assessment of gut microbiota in circadian rhythm disorders: a cross-sectional clinical study.Frontiers in cellular and infection microbiology · 2025Article
- Microbial Interactions with Intestinal Lipid Digestion and Absorption: Emerging Targets for Metabolic Disorders.Research (Washington, D.C.) · 2025Review
- Bile Acid Signaling in Metabolic and Inflammatory Diseases and Drug Development.Pharmacological reviews · 2024Review
- Functional metabolomics characterizes the contribution of farnesoid X receptor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome.Archives of toxicology · 2024Article
- Apolipoprotein A-IV and its derived peptide, T55-121, improve glycemic control and increase energy expenditure.Life metabolism · 2024Article
- Gut microbiota and therapy for obesity and type 2 diabetes.Frontiers in endocrinology · 2024Review
- Research progress on the relationship between bile acid metabolism and type 2 diabetes mellitus.Diabetology & metabolic syndrome · 2023Review
- Hepatic lipid-associated macrophages mediate the beneficial effects of bariatric surgery against MASH.Research square · 2023Article
- Mechanisms of bariatric surgery for weight loss and diabetes remission.Journal of diabetes · 2023Review
- Novel Insights into the Physiology of Nutrient Sensing and Gut-Brain Communication in Surgical and Experimental Obesity Therapy.Obesity surgery · 2023Review
- Review
- Intestinal Farnesoid X Receptor Modulates Duodenal Surface Area but Does Not Control Glucose Absorption in Mice.International journal of molecular sciences · 2023Article
- Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH.Scientific reports · 2023Article
- Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice.Communications biology · 2023Article
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Authors and funding
18 authors at 4 institutions in 2 countries.
Lili DingShanghai Key Laboratory of Complex Prescriptions and Ministry of Education Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.ORCID 0000-0002-4831-3300
Eryun ZhangShanghai Key Laboratory of Complex Prescriptions and Ministry of Education Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.ORCID 0000-0003-3862-3839
Qiaoling YangShanghai Key Laboratory of Complex Prescriptions and Ministry of Education Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.ORCID 0000-0002-7462-2510
Lihua JinDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010.ORCID 0000-0002-2685-6048
Kyle M SousaDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010.ORCID 0000-0001-9879-8740
Bingning DongDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.
Yangmeng WangDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010.
Jui TuDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010.
Xiaoxiao MaDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010.
Jingyan TianDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010.ORCID 0000-0002-0569-7615
Hongli ZhangDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010.ORCID 0000-0002-9492-4225
Zhipeng FangDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010.
Ana GuanDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010.
Yixin ZhangShanghai Key Laboratory of Complex Prescriptions and Ministry of Education Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.ORCID 0000-0001-7554-334X
Zhengtao WangShanghai Key Laboratory of Complex Prescriptions and Ministry of Education Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
David D MooreDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030; moore@bcm.edu yl7@shutcm.edu.cn whuang@coh.org.ORCID 0000-0002-5151-9748
Li YangShanghai Key Laboratory of Complex Prescriptions and Ministry of Education Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; moore@bcm.edu yl7@shutcm.edu.cn whuang@coh.org.ORCID 0000-0002-5484-0895
Wendong HuangDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010; moore@bcm.edu yl7@shutcm.edu.cn whuang@coh.org.ORCID 0000-0003-3735-9466
City Of Hope National Medical Center · USShanghai University of Traditional Chinese Medicine · CNBaylor College of Medicine · USShanghai Jiao Tong University · CN
Funding
MiRNAs in hepatocellular carcinoma development and treatmentR01CA139158 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI HUANG, WENDONG, YU, HUA E · 2011 to 2021
$3.7MBile acids and metabolic surgeryR01DK124627 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI HUANG, WENDONG · 2020 to 2024
$2.0MNCI NIH HHS R01 CA139158NIDDK NIH HHS R01 DK124627
Abstract
Vertical sleeve gastrectomy (VSG) is one of the most effective and durable therapies for morbid obesity and its related complications. Although bile acids (BAs) have been implicated as downstream mediators of VSG, the specific mechanisms through which BA changes contribute to the metabolic effects of VSG remain poorly understood. Here, we confirm that high fat diet-fed global farnesoid X receptor (
Indexed as
AnimalsBile Acids and SaltsCholestanetriol 26-MonooxygenaseDiet, High-FatGastrectomyHumansLipid MetabolismLipidsMiceMice, KnockoutObesity, MorbidReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearWeight LossBile Acids and SaltsCholestanetriol 26-MonooxygenaseCyp27a1 protein, mouseLipidsReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and Nuclearbariatric surgerybile acidscyp27a1farnesoid X receptorlipid absorption
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.