Evidence map›Paper›PMID 33526676›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Matthew H Foley, Sarah O'Flaherty, Garrison Allen, Alissa J Rivera, Allison K Stewart, Rodolphe Barrangou, Casey M Theriot

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 174 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Bile Acid Metabolism as a Unifying Readout for Diet, Microbiome Function, and Gastrointestinal Disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Letter to the Editor: Deciphering macrophage heterogeneity and optimizing probioticsWorld journal of gastrointestinal pharmacology and therapeutics · 2026
    Article
  18. Review
  19. Review
  20. Review

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Matthew H FoleyDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27695.
Sarah O'FlahertyDepartment of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, Raleigh, NC 27695.ORCID 0000-0001-8629-0675
Garrison AllenDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27695.
Alissa J RiveraDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27695.
Allison K StewartMolecular Education, Technology and Research Innovation Center, North Carolina State University, Raleigh, NC 27695.ORCID 0000-0003-3200-309X
Rodolphe BarrangouDepartment of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, Raleigh, NC 27695; rbarran@ncsu.edu cmtherio@ncsu.edu.ORCID 0000-0002-0648-3504
Casey M TheriotDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27695; rbarran@ncsu.edu cmtherio@ncsu.edu.
North Carolina State University · US

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
GASTROENTEROLOGY RESEARCH TRAININGT32DK007737 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEHZAD Z. SHEIKH · 1996 to 2026
$7.8M
NIDDK NIH HHS P30 DK034987NIDDK NIH HHS T32 DK007737
6 · The paper itself

Abstract

Primary bile acids (BAs) are a collection of host-synthesized metabolites that shape physiology and metabolism. BAs transit the gastrointestinal tract and are subjected to a variety of chemical transformations encoded by indigenous bacteria. The resulting microbiota-derived BA pool is a mediator of host-microbiota interactions. Bacterial bile salt hydrolases (BSHs) cleave the conjugated glycine or taurine from BAs, an essential upstream step for the production of deconjugated and secondary BAs. Probiotic lactobacilli harbor a considerable number and diversity of BSHs; however, their contribution to

Indexed as

AmidohydrolasesEcosystemGastrointestinal MicrobiomeGenetic FitnessHost-Pathogen InteractionsHumansLactobacillusProbioticsSubstrate SpecificityAmidohydrolasescholoylglycine hydrolaseAcidophilusbile acidbile salt hydrolasegasseriLactobacillus

Identifiers

PMID33526676
PMCPMC8017965
OpenAlexW3128625686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.