ArticleThe Journal of rheumatology2021
Joint Association of Moderate-to-vigorous Intensity Physical Activity and Sedentary Behavior With Incident Functional Limitation: Data From the Osteoarthritis Initiative.
Article in The Journal of rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A Telehealth Physical Therapy Intervention to Increase Physical Activity in Adults With Knee OA: The Delaware PEAK Randomized Controlled Trial.The Journal of orthopaedic and sports physical therapy · 2025Trial
- The Relation of Within-Day Physical Activity Patterns With All-Cause Mortality in Adults With Knee Osteoarthritis: Findings From the Osteoarthritis Initiative.Arthritis care & research · 2026Observational
- Sit-to-Stand Performance, Moderate-to-Vigorous Physical Activity, and Health-Related Quality of Life in Knee Osteoarthritis: A Prospective Mediation Analysis.Preventing chronic disease · 2026Article
- Comparisons of hip-worn and ankle-worn accelerometers on measuring physical activity and their correlations with perceived activity level in community-dwelling older adults.Gait & posture · 2026Article
- Self-reported sedentary time and its influencing factors among patients with knee osteoarthritis: a cross-sectional survey.Scientific reports · 2025Article
- Relationship between Changes in Physical Activity and Knee Health 18 Months after ACL Reconstruction.Medicine and science in sports and exercise · 2025Article
- The relation of activity patterns with incident slow gait speed over 4 years in adults with knee osteoarthritis: Data from the Osteoarthritis Initiative.Osteoarthritis and cartilage · 2025Article
- Sedentary Behavior Patterns After ACL Reconstruction.International journal of exercise science · 2025Article
- Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007-2020 and Mendelian randomization analysis.Frontiers in public health · 2024Article
- Causal effect of physical activity and sedentary behaviors on the risk of osteoarthritis: a univariate and multivariate Mendelian randomization study.Scientific reports · 2023Article
- The association between basal metabolic rate and osteoarthritis: a Mendelian randomization study.BMC medical genomics · 2023Article
- Assessment of causal effects of physical activity on the risk of osteoarthritis: a two-sample Mendelian randomization study.BMC medical genomics · 2023Article
- Physical Activity, Sedentary Behavior, and Osteoarthritis: A Two-Sample Mendelian Randomization Analysis.Iranian journal of public health · 2023Article
- Associations of Mutually Exclusive Categories of Physical Activity and Sedentary Behavior with Body Composition and Fall Risk in Older Women: A Cross-Sectional Study.International journal of environmental research and public health · 2023Article
- FDA/Arthritis Foundation osteoarthritis drug development workshop recap: Assessment of long-term benefit.Seminars in arthritis and rheumatism · 2022Review
- Linking physical activity with clinical, functional, and structural outcomes: an evidence map using the Osteoarthritis Initiative.Clinical rheumatology · 2022Review
- Predictors of resilience in older adults with lower limb osteoarthritis and persistent severe pain.BMC geriatrics · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo examine the joint association of moderate-to-vigorous intensity physical activity (MVPA) and sedentary behavior with the risk of developing functional limitation 4 years later in adults with knee osteoarthritis (OA).
methodsUsing 48-month (baseline) accelerometry data from the Osteoarthritis Initiative, we classified participants as Active-Low Sedentary (≥ 1 10-min bout/week of MVPA, lowest tertile for standardized sedentary time), Active-High Sedentary (≥ 1 10-min bout/week of MVPA, top 2 tertiles for standardized sedentary time), Inactive-Low Sedentary (zero 10-min bouts/week of MVPA, lowest tertile for standardized sedentary time), and Inactive-High Sedentary (zero 10-minute bouts/week of MVPA, top 2 tertiles for standardized sedentary time) groups. Functional limitation was defined as > 12 seconds for the 5-repetition sit-to-stand test (5XSST) and < 1.22 m/s gait speed during the 20-meter walk test. To investigate the association of exposure groups with risk of developing functional limitation 4 years later, we calculated adjusted risk ratios (aRR; adjusted for potential confounders).
resultsOf 1091 and 1133 participants without baseline functional limitation, based on the 5XSST and 20-meter walk test, respectively, 15% and 21% developed functional limitation 4 years later. The Inactive-Low Sedentary and Inactive-High Sedentary groups had increased risk of developing functional limitations compared to the Active-Low Sedentary and Active-High Sedentary groups. The Inactive-Low Sedentary group had 72% (aRR 1.72, 95% CI 1.00-2.94) and 52% (aRR 1.52, 95% CI 1.03-2.25) more risk of developing functional limitation based on the 5XSST and 20-meter walk test, respectively, compared to the Active-Low Sedentary group.
conclusionRegardless of sedentary category, being inactive (zero 10-min bouts/week in MVPA) may increase the risk of developing functional limitation in adults with knee OA.
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